单双相抑郁智能损害的对照研究

【目的】 研究单?双相抑郁患者治疗前后的智能损害特点及其影响因素?【方法】 对27例单相抑郁(单相组)和30例双相抑郁患者(双相组)予以3个月药物治疗,治疗前后分别评定24项汉密尔顿抑郁量表(HAMD)?中国修订韦氏成人智力测验量表(WAIS-RC),与26名正常对照进行比较?【结果】 ①治疗前,病例组在知识?领悟?算术?数字广度?词汇?言语智商?填图?木块图?相似?数字符号?操作智商?智商分测验上差于正常对照组(P < 0.05),领悟?算术分测验是单相组差于对照组(P < 0.05),其余均是单双相抑郁组差于对照组;治疗后,病例组在知识?言语智商?木块图?相似?数字符号?操作智商?智商分测验上差于正常对照组(P < 0.05),知识?言语智商?木块图分测验上单相组差于对照组(P < 0.05),其余均是单双相抑郁组差于对照组;治疗前后,单相组均在知识分测验上差于双相组(P < 0.05);②多元回归分析显示,单相组治疗前,领悟?算术?相似?图片排列?智商与阻滞因子分呈负相关;数字广度?数字符号?操作智商与认识障碍因子得分呈负相关;木块图与睡眠障碍因子得分呈负相关?双相组治疗前,知识?算术?相似?数字广度?词汇?言语智商?智商与认识障碍因子得分呈负相关;图片排列?操作智商与躯体化/焦虑因子得分呈负相关;图片拼凑与日夜变化因子得分呈正相关;领悟与阻滞因子分呈负相关;填图与睡眠障碍因子分呈负相关?【结论】 单双相抑郁都存在特质性和状态性并存的智能障碍,均受临床症状影响,但损害存在差异?

A Control Study of Intelligence about Unipolar Depression and Bipolar Depression

【Objective】 To explore the intelligence and the influential factors in unipolar depression and bipolar depression.【Methods】 Twenty-seven unipolar depression patients and 30 bipolar depression patients were taken the drug treatment for 12 weeks, and 26 healthy people were involved as controls. The case group was assessed with the 24-item Hamilton Depression Scale (HAMD) and Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC).【Results】 In comparison with the controls, before treatment, and case group had lower scores in knowledge, understanding, arithmetic, digit span, vocabulary, VIQ, mapping, block diagram, similarities, digit symbol, PIQ, and IQ tests; after treatment, case group had lower scores in knowledge, VIQ, block diagram, similarities, digit symbol, PIQ, and IQ tests. Before and after treatment, unipolar depression patients had lower scores in knowledge test of unipolar depression patients. Linger regression analysis showed that before treatment of unipolar depression patients, the scores ofcomprehend, arithmetic, similarities, picture arrangement, and IQ were negatively correlated to the retardation factor score, the scores of digit span, digit symbol and PIQ was negatively correlated to recognizing obstacles factor score, the scores of block diagram was negatively correlated to sleeping disturbance factor score. To bipolar depression patients before treatment, the scores ofknowledge, arithmetic, similarities, digit span, vocabulary, VIQ, and IQ were negatively correlated to recognizing obstacles factor score, the scores of picture arrangement, PIQ were negatively correlated to somatic/anxiety factor score, the scores of picture together was positively correlated to day and night changes score, the scores of comprehend was negatively correlated to the retardation factor score, the scores of mapping was negatively correlated to sleep disturbance factor score. 【Conclusion】 It is common that unipolar depression patients and bipolar depression patients have intelligence disfonction, the disfounction is governed by the clinical syptoms of the impact trait and status coexist.