多发性骨髓瘤继发急性淋巴细胞性白血病1例并文献复习

目的：探讨多发性骨髓瘤（MM）及其继发急性淋巴细胞白血病（ALL）的临床特点、病因、诊断、治疗及预后。方法：临床诊断1例MM继发急性单核性细胞白血病（AML），并就相关文献进行复习。结果：患者确诊MM后5年转化为ALL，经DVP，CVAD，HD—MTX／Arac等方案化疗后取得完全缓解，并行非清髓性骨髓移植获得成功。结论：MM在老年恶性血液病中比较常见，但易被误诊。MM继发ALL是一种罕见疾病，免疫分型在诊断中起重要作用，治疗效果差，如有条件，应尽早行造血干细胞移植。

Secondary acute lymphoblastic leukemia in multiple myeloma one case report and review literature

Objective:To investigate the clinical characteristics,pathogenesis,diagnosis,therapheutics and prognosis of multiple myeloma(MM) and secondary acute lymphoblastic leukemia (ALL)in it. Methods:One case of ALL secondary to MM was diagnosed and literatures were reviewed.Results:The patient was found ALL after having been diagnosed MM five years ago.He achieved complete remission with DVP/CVAD/HD-MTX(Arac) regimens,moreover,he succeeded in non-myeloablative hematopoietic stem cell transplantation(NST). Conclusion:MM is a frequent malignant hematopathy in old people,but it is often misdiagnosed. However, ALL secondary to MM is a rare disease.Flow cytometry is helpful to diagnose.Chemotherapy is poor effective,it is necessary to take hematopoietic stem cell transplantation if conditions permissible.