The comparison of in the vitro effect of imipenem or meropenem combined with ciprofloxacin or levofloxacin against multidrug-resistant Pseudomonas aeruginosa strains |
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Authors: | Erdem Ilknur Kaynar-Tascioglu Jale Kaya Birsen Goktas Pasa |
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Affiliation: | Clinic of Infectious Disease and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, No: 153/4, 81150 Baglarbasi, Istanbul, Turkey. ilknurerdem@hotmail.com |
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Abstract: | This study evaluated the in vitro effects of the combination of a carbapenem (imipenem or meropenem) with a quinolone (ciprofloxacin or levofloxacin) using a microbroth dilution chequerboard technique and multidrug-resistant Pseudomonas aeruginosa strains. The ciprofloxacin and meropenem combination was only synergistic against 2 strains (6.2%) and ciprofloxacin and imipenem against 1 strain (3.1%). Levofloxacin and imipenem or meropenem were not synergistic for against any strain. None of the combinations showed an antagonistic effect. |
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