Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex |
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| Authors: | Wu J Y Sutherling W W Koh S Salamon N Jonas R Yudovin S Sankar R Shields W D Mathern G W |
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| Affiliation: | Division of Pediatric Neurology, The Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. joycewu@mednet.ucla.edu |
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| Abstract: | The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy. |
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