Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection |
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| Authors: | Ragin A B Wu Y Storey P Cohen B A Edelman R R Epstein L G |
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| Affiliation: | Department of Radiology, The Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ann-ragin@northwestern.edu |
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| Abstract: | Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-alpha), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-alpha) and putamen (hematocrit). |
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