HLA-DQB1等位基因多态性与复发性尖锐湿疣的关系

【摘要】目的 研究HLA-DQB1等位基因DQB1*0501、DQB1*0502、DQB1*0201、DQB1*0402与复发性尖锐湿疣间的关系，为寻找尖锐湿疣的易感基因提供线索。方法 应用PCR-SSP技术检测84例复发性尖锐湿疣患者和107例正常人的HLA-DQB1等位基因DQB1*0501、DQB1*0502、DQB1*0201、DQB1*0402。结果 尖锐湿疣复发组DQB1*0501等位基因频率明显降低（8.3% vs 21.5%，P<0.05），DQB1*0201等位基因频率明显降低（0% vs 9.3%，P<0.01），另两等位基因在两组之间无明显差异，提示DQB1*0501与DQB1*0201与尖锐湿疣复发相关。结论 HLA 多态性可能是与尖锐湿疣复发有关的宿主遗传因素。

Relation between HLA-DQB1 polymorphism and condyloma acuminatum recurrence

【Abstract】Objective To investigate the association of HLA-DQB1 allele and recurrence of condyloma acuminata, so as to provide some evidence for the seeking susceptibility genes or resistant genes of condyloma acuminata. Methods Eighty four patients with recurrent condyloma acuminata were investigated for HLA-DQB1 genes by PCR-SSP technique; it was compared with 107 normal healthy subjects. Results Frequency of DQB1*0501 allele was 8.3% in patient group, which was significantly lower than that in control group (21.5%) (P<0.05), and frequency of DQB1*0201 allele was decreased in patient group (patient 0%, control 9.3%, P<0.01), while frequencies of other investigated DQB1 allele were not significantly different (P>0.05). The result showed that the susceptibility to condyloma acuminata is negatively associated with the alleles of DQB1*0501 and DQB1*0201. ConclusionsThe results suggest that HLA class II polymorphisms may be involved in the recurrence of condyloma acuminata.