云南白药联合泮托拉唑治疗急性上消化道出血

目的:观察云南白药联合泮托拉唑治疗急性上消化道出血的临床疗效.方法:将符合病例入选标准的120例患者随机分为观察组、对照组各60例.两组患者入院后即给予止血、输液和(或)输血等对症治疗,在急性活动期禁食水,对有呕血者常规禁食并留置胃管.对照组同时给予泮托拉唑,先以泮托拉唑80 mg+生理盐水100 mL快速静滴,再以8mg·h-1速度静滴3d.观察组同时给予云南白药,0.5 g/次,6次/d,ig,连用3d.两组均以3d为1个疗程,治疗1个疗程后观察疗效.结果:观察组显效率73.33％,总有效率93.33％；对照组显效率26.67％,总有效率70.00％.两组显效率、总有效率有差异(P＜0.05).止血时间、住院时间观察组分别为(28.8 ±3.4)h、(6.68 ±0.5)d,对照组分别为(52.6±5.7)h,(9.33±3.2)d,观察组＜对照组(P＜0.05)；输血量及出血量观察组分别为(14.2±3.4),(451.6 ±50.8) mL,对照组分别为(29.8±5.3)(612.3±68.5) mL,观察组小于对照组(P＜0.05).血清超敏C反应蛋白(hs-CRP)和皮质醇水平治疗后均显著降低(P＜0.05),但观察组降低更明显(P＜0.05).结论:云南中药联合泮托拉唑治疗急性上消化道出血临床疗效显著,可缩短止血时间,减少输血量.

Yunnan Baiyao Combined with Pantoprazole in Treatment of Acute Upper Gastrointestinal Hemorrhage

Objective: To observe the effect of Yunnan Baiyao Combined with pantoprazole in treatment of acute upper digestive tract hemorrhage. Method: One hundred and twenty patients were randomly divided into the observation group and the control group, 60 cases in each group. Two groups of patients after admission were treated with hemostasis, infusion and (or) transfusion. In acute period, fasting or indwelling gastric tube were carried out for patients with hematemesis. The control group at the same time give pantoprazole intravenous drip: first with pantoprazole 80 mg saline 100 mL rapid intravenous infusion, again with 8 mg·h speed continuous infusion for 3 days. In observation group,Yunnan Baiyao was orally given at the same time, 0.5 g each time, 6 times daily, for 3 days. The 2 groups were treated for 3 days as 1 course of treatment, the therapeutic effects were observed after 1 course of treatment. Result: The observation group showed an efficacy of 73.33%, the total effective rate was 93.33%; in the control group marked effective rate was 26.67%, the total efficacy was 70%. In two groups, the total efficacies appearred to be differences(P<0.05 ). Bleeding time, duration of hospitalization in observation group were (28.8±3.4) h, (6.68±0.5) d respectively,in control group (52.6±5.7) h, (9.33±3.2) d respectively. The data in observation group were shorter than that in control group(P<0.05 ).Volume of blood transfusion and bleeding volume in obseruation group were (14.2±3.4) U,(451.6±50.8) mL, in control group were(29.8±5.3)U, (612.3±68.5) mL (P<0.05). Serum high sensitive C reactive protein (hs-CRP) and cortisol levels after treatment were significantly reduced (P<0.05), but the observation group were more significantly reduced (P<0.05). Conclusion: Yunnan Baiyao combined with pantoprazole in treatment of acute upper gastrointestinal hemorrhage shows remarkable clinical curative effect with shortened bleeding time and decreased amount of blood transfusion.