关联度最强药物配伍的中医止呕类方数据挖掘

目的:在古今中医文献中寻找止呕方剂配伍规律与用药特点,为中药止呕新药的开发提供理论支持。方法:收录古今止呕类方剂985首建立止呕类方剂数据库,运用相关置信度规则,对中医止呕方剂药物配伍的数据进行挖掘,利用剪枝方法筛选关联度最强的数据。结果:最常用的单味药物为生姜使用频率高达61.23%。关联性最强的核心药对是茯苓配伍姜半夏,其相关置信度为0.114 4。关联度最强的药组为生姜、姜半夏、茯苓。结论:生姜、姜半夏、茯苓,其相关置信度为0.295 4是中医止呕方剂中最常合用的药物配伍,其3种药物间存在极强的关联性,张仲景创制的小半夏加茯苓汤被证实是中医止呕的核心药组。

Rule of Remedy for Vomiting in Science of Traditional Chinese Medicine Formu as by Data Mining Based on Both Association and Correlation Rule

Objective: To look for the rules of compatibility of medicines in historical prescriptions which treat vomiting, mining out new knowledge in science of traditional Chinese medicine(TCM) formulas, providing support for making new TCM remedy for vomiting. Method: Created a TCM formulas database to treat vomiting by collecting 985 TCM formulas. A threshold level datamining method which based on both association and correlation rule is used, to mining rule of compatibility of medicines in database of historical prescriptions for vomiting. Result: The most used drug is Zingiber officinale,the using frequency of Z. officinale is 61.23%. The most association and correlation couple of drugs are Poria cocos(Schw.)Wolf and Pinellia ternate(Thunb.)Breit.the correlation-confidence of this couple is 0.114 4.The most association and correlation group of drugs are Z. officinale and P. cocos and P. ternate, the correlation-confidence of this group is 0.295 4, Conclusion: The group of drugs which contain Z. officinale. and P. ternate and P. cocos is most used to treat vomiting. The ternate added in the P. cocos soup, which is ancient famous TCM formulas created by ancient great doctor ZHANG Zhong-jing, is proved that it is the key compatibility of drugs to treat vomiting.