| 补中益气丸中氨基酸类成分指纹图谱 |
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| 引用本文： | 柯雪红,花汝凤,陈锦富,杨小催,陈为.补中益气丸中氨基酸类成分指纹图谱[J].中国实验方剂学杂志,2012,18(14):81-84. |
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| 作者姓名： | 柯雪红 花汝凤 陈锦富 杨小催 陈为 |
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| 作者单位： | 1. 广州中医药大学第一附属医院,广州,510405
2. 广州星群(药业)股份有限公司,广州,5102882 |
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| 基金项目： | 广东省中医药局科研课题(2008215) |
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| 摘 要： | 目的:对5个不同药厂生产的20批补中益气丸氨基酸类成分指纹图谱进行比较研究.方法:以柱前衍生化HPLC,测定不同药厂补中益气丸氨基酸类成分指纹图谱,提取指纹图谱数字化信息,采用相似度分析、聚类分析等多种统计方法分析不同药厂产品特征.结果:不同药厂补中益气丸氨基酸类成分指纹图谱中有9个共有峰,相似度在0.8 ～1.00；A药厂样品中氨基酸类成分较多,指纹图谱特征与标准汤剂指纹图谱相似度最高.结论:方法稳定、可靠、重复性好,为区分不同药厂补中益气丸提供参考.
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| 关 键 词： | 补中益气丸 氨基酸 指纹图谱 相似度分析 聚类分析 |
| 收稿时间： | 2011/12/9 0:00:00 |
Fingerprint Chromatogram of Amino Acids Compounds Analysis in Different Brands Buzhongyiqi Pills |
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| KE Xue-hong,HUA Ru-feng,CHEN Jin-fu,YANG Xiao-cui and CHEN Wei.Fingerprint Chromatogram of Amino Acids Compounds Analysis in Different Brands Buzhongyiqi Pills[J].China Journal of Experimental Traditional Medical Formulae,2012,18(14):81-84. |
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| Authors: | KE Xue-hong HUA Ru-feng CHEN Jin-fu YANG Xiao-cui and CHEN Wei |
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| Institution: | The Fist Hospitol Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;Xingqun Medcine Co. Ltd of Guangzhou, Guangzhou 510288, China;The Fist Hospitol Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;The Fist Hospitol Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;The Fist Hospitol Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China |
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| Abstract: | Objective: To analyze the fingerprint chromatogram of amino acids compounds in different brands Buzhongyiqi pills and offer reference to distinguishing them. Method: By 6-aminoqtiinoly-N-hydroxysuccinimdyl carbamate(AQC) according to pre-column derivatization HPLC method to establish the fingerprint chromatogram of amino acids compounds.distilling the digital info of fingerprint chromatogram and analyzing with SPSS. Result: nine co-peaks on the HPLC fingerprints of Buzhongyiqi pills were indicated. The results of similarity analysis were 0.8-1.00. Conclusion: This method is available for quality evalution and can control the quality of BuzhongYiqi pills. |
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| Keywords: | Buzhongyiqi pills amino acids compounds fingerprint chromatogram similarity analysis cluster analysis |
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