结核分支杆菌临床分离株多耐药特点研究

目的 测定武汉和海口结核分支杆菌分离株对５种抗结核药的ＭＩＣ并分析其耐药特征。方法 ＢＡＣＴＥＣ技术和改良罗氏培养用于ＭＩＣ的测定。结果 ６６株结核菌对ＩＨＮ，ＳＭ，ＰＡＳ，ＥＭＢ和ＥＦＰ的耐药率分别是３９．４％，２４．２％，１６．７％，２４．２％和３７．９％。武汉和海口分离株的耐药率无显著性差异（Ｐ〉０．０５）。总耐药率为５７．６％。多耐药率为４２．２％。多耐药株占总耐药株的７３．７％。多耐药菌

CHARACTERAZATIONS OF MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY TO 5 DRUGS BY DETERMINATION OF THEIR MIC

Objective To determine the INH,SM, PAS, EMB and RFP minimal inhibitory concentrations to Mycobacterium tuberculosis and analyse the drug-resisitant patterns. Method BACTEC techniques and improved L-J culture were employed to MIC deteminations. Result Among 66 isolates of Mtuberculosis, resistant rates to INH, SM, PAS,EMB and RFP were 39.4%, 24.2%,16.7%,24 .2% and 37. 9 %. There was no significant difference betweenthe Wuhan and Haikou isolate resistant rates. Total resistant rate was 57. 6 %. The multi-drug resistant(MDR) rate of this panel of isolates was 42.2%. MDR constitional rate was 73. 7 %. driong MDR isolates, resistant rates to both INH and RFP were very high, among strains to the INH and RFP, MDR rate were also high.Conclusion Both resistant rate and MDR rate were high. The MDR may be associated with their resistace to INH and/or RFP.