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上皮间质转化与肿瘤侵袭转移关系的研究进展
引用本文:孙丹,辛彦. 上皮间质转化与肿瘤侵袭转移关系的研究进展[J]. 现代肿瘤医学, 2011, 19(10): 2088-2091. DOI: 10.3969/j.issn.1672-4992.2011.10.62
作者姓名:孙丹  辛彦
作者单位:中国医科大学附属第一医院肿瘤研究所胃肠肿瘤病理研究室,普通外科研究所肿瘤病理研究室,辽宁,沈阳,110001
基金项目:国家自然科学基金,国家自然科学基金,国家自然科学基金,教育部高等学校博士学科点专项科研基,辽宁省高等学校攀登学者计划,沈阳市科学技术计划项目
摘    要:上皮间质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞失去极性,失去与基底膜的连接等上皮表型,通过特定程序转化为具有间质表型的生物学过程,从而获得了较高的迁移与侵袭、抗凋亡和降解细胞外基质的能力,与肿瘤的侵袭转移密切相关。参与这一过程的细胞内信号转导途径主要有:TGF-β信号途径、PI3K/AKT途径、Notch信号通路、Wnt信号通路等。本文就EMT在肿瘤侵袭转移中的作用及其分子机制的研究作一综述。

关 键 词:上皮间质转化  信号通路  侵袭  转移

The research progress of the relation between epithelial-mesenchymal transition and tumor invasion or metastasis
SUN Dan,XIN Yan. The research progress of the relation between epithelial-mesenchymal transition and tumor invasion or metastasis[J]. Journal of Modern Oncology, 2011, 19(10): 2088-2091. DOI: 10.3969/j.issn.1672-4992.2011.10.62
Authors:SUN Dan  XIN Yan
Affiliation:SUN Dan,XIN Yan Gastrointestinal Tumor Pathology Laboratory of Cancer Institute,Department of Tumor Pathology of General Surgery Institute,No.1 Hospital of China Medical University,Liaoning Shenyang 110001,China.
Abstract:Epithelial-mesenchymal transition(EMT) describes the loss of the epith-elial cell polarity and epithelial phenotype,such as the connections with the basement membrane.It is a biological process to express the mesenchymal phenotype through a specific program and gain the abilities of invasion,metastasis,anti-apoptosis and extracellular matrix degradation which are associated with the tumor invasion and metastasis.The cell signaling pathways involved in the process including TGF-β signaling pathway,PI3K/AKT pathway,Notch signaling pathway,Wnt signaling pathway and so on.This review summarizes the current progress in the research field of EMT and the role of EMT in tumor invasion and metastasis.
Keywords:epithelial-mesenchymal transitions  signaling pathway  invasion  metastasis  
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