| microRNA在结直肠癌中的研究进展 |
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| 引用本文： | 毕德利,王亚旭.microRNA在结直肠癌中的研究进展[J].现代肿瘤医学,2011,19(10):2117-2120. |
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| 作者姓名： | 毕德利 王亚旭 |
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| 作者单位： | 重庆医科大学附属第二医院普外科,重庆,400010 |
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| 摘 要： | microRNA(miRNA)是一类长21-25nt核苷酸的内源性非编码调控RNA,通过与靶细胞mRNA的3’UTR完全互补导致mRNA降解,或不完全互补结合阻断mRNA翻译,参与细胞发育、增殖、分化和凋亡。miRNA具有癌基因和抑癌基因的作用,若干miRNA直接或间接参与结直肠癌的发生和发展,miRNA表达谱与结直肠癌的诊断、分期、进展和预后密切相关。
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| 关 键 词： | miRNA 结直肠癌 基因表达 生物治疗 |
The research in colorectal cancer of microRNA |
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| BI Deli,WANG Yaxu.The research in colorectal cancer of microRNA[J].Journal of Modern Oncology,2011,19(10):2117-2120. |
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| Authors: | BI Deli WANG Yaxu |
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| Institution: | BI Deli,WANG Yaxu The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China. |
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| Abstract: | microRNA is a kind of the endogenous non-coding RNA of regulation with 21-25nt long nucleotide,through fully complementary with the 3'UTR of target cells mRNAlead to mRNA degradation,or not fully complementary with mRNA block mRNA translation,to involve in cell growth,proliferation,differentiation and apoptosis.miRNA are oncogenes and tumor suppressor genes,some miRNA directly or indirectly involve in the development and progression of colorectal cancer,the expression profiling of miRNA is closely related w... |
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| Keywords: | miRNA colorectal cancer gene expression biological therapy |
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