体腔热灌注化疗治疗恶性胸腹腔积液临床研究

目的:研究体腔热灌注化疗治疗恶性胸腹腔积液的疗效与不良反应。方法:67例恶性胸腹腔积液患者分为治疗组(35例)和对照组(32例)。胸腹腔穿刺行闭式引流干净胸腹腔积液后,治疗组给予5-氟尿嘧啶1000mg加上43℃-45℃的生理盐水,胸腔积液患者需2000ml-2500ml生理盐水;腹腔积液患者需2500ml-3000 ml生理盐水,以HGGZ-102体腔热灌注治疗系统注入胸腹腔,使进入胸腹腔的液体温度维持在41℃-43℃,循环2h;对照组给予生理盐水100ml+5-氟尿嘧啶1000mg胸腹腔注入。两组均每周灌注1次,连续灌注3周,评定疗效。结果:治疗组有效率88.6%,Karnofsky评分增加率85.7%;对照组有效率62.5%,Karnofsky评分增加率59.4%。治疗组胸腹腔积液控制率、Karnofsky评分增加率均优于对照组(P<0.05)。两组不良反应无明显差异。两组生存期无统计学差异(P>0.05)。结论:体腔热灌注化疗治疗恶性胸腹水近期疗效好且安全。

Clinical study of hyperthermic perfusion chemotherapy for body cavity in the treatment of malignant pleural effusion and malignant celiac effusion

Objective:To observe the efficacy and side effects of hyperthermic perfusion chemotherapy for body cavity in the treatment of malignant pleural effusion and celiac effusion.Methods: Sixty-seven patients with malignant pleural effusion and celiac effusion were divided into treatment group(n=35)and control group(n=31).In treatment group,after malignant pleural effusion and celiac effusion was drained,normal saline 2000-3000ml with 5-fluorouracil 1000mg heated to 43-45℃ was perfused into pleural cavity and peritoneal cavity,maintaining 41-43℃ with HGGZ-102 body cavity perfusion therapy machine and circulation heating 120 minutes.In control group patients were only given normal saline 100ml and 5-fluorouracil 1000mg.For both groups,this therapeutic schedule repeated once a week,for 3 weeks.Results: The effective rate was 88.6%,and Karnofsky score increased rate was 85.7% in treatment group,while 62.5%,59.4% in control group(P<0.05).The toxic and side effects of two groups had no significant difference.Survival in two groups was not statistically significantly different(P>0.05).Conclusion: The hyperthermic perfusion chemotherapy for body cavity in the treatment of malignant pleural effusion and celiac effusion has good efficacy,and safety.