| 亚砷酸联合GDP方案治疗难治性或复发性非霍奇金淋巴瘤的疗效观察 |
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| 引用本文： | 丁富强,乔红梅,李晓霞,李恩孝.亚砷酸联合GDP方案治疗难治性或复发性非霍奇金淋巴瘤的疗效观察[J].现代肿瘤医学,2011,19(10):2076-2078. |
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| 作者姓名： | 丁富强 乔红梅 李晓霞 李恩孝 |
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| 作者单位： | 1. 陕西电子四零九医院肿瘤科,陕西,宝鸡,721006
2. 西安交通大学医学院第一附属医院肿瘤科,陕西,西安,710061 |
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| 摘 要： | 目的:观察亚砷酸(三氧化二砷,As2O3)联合GDP方案(吉西他滨,顺铂,地塞米松)治疗难治性或复发性非霍奇金淋巴瘤(non-hodgkin’s lymphoma,NHL)的有效率。方法:23例难治性或复发性非霍奇金淋巴瘤(NHL),给予吉西他滨1000mg/m2,第1和第8天,顺铂25mg/m2第1-3天,地塞米松20mg/m2,第1-5天,As2O310mg/d,第1-14天。21天为1个周期。结果:完全缓解9例,部分缓解6例,总有效率65.22%。肿瘤中位进展时间6个月,1年生存率39.13%。不良反应主要为血液学毒性。结论:亚砷酸联合GDP方案是治疗难治性或复发性非霍奇金淋巴瘤较为安全有效的化疗方案。
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| 关 键 词： | 亚砷酸 GDP 非霍奇金淋巴瘤 |
Efficacy of Arsenic Trioxide combined with GDP regimen for patients with aggressive relapsed or refractory non-Hodgkin's lymphoma |
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| DING Fuqiang,QIAO Hongmei,LI Xiaoxia,LI Enxiao.Efficacy of Arsenic Trioxide combined with GDP regimen for patients with aggressive relapsed or refractory non-Hodgkin's lymphoma[J].Journal of Modern Oncology,2011,19(10):2076-2078. |
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| Authors: | DING Fuqiang QIAO Hongmei LI Xiaoxia LI Enxiao |
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| Institution: | DING Fuqiang1,QIAO Hongmei1,LI Xiaoxia1,LI Enxiao2 1Department of Oncology,Shaanxi Electronic 409 Hospital,Shaanxi Baoji 721006,China,2Department of Oncology,First Affiliated Hospital of Medical College of Xi'an jiaotong University,Shaanxi Xi'an 710061,China. |
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| Abstract: | Objective:To evaluate the efficacy and safety of chemotherapy regimen with arsenic trioxide(As2O3) combined with GDP(gemcitabine,cisplatin and dexamethasone) for patients with aggressive relapsed or refractory NHL.Methods: All 23 patients with relapsed or refractory NHL were observed,23 patients were treated by gemcitabine 1000 mg/m2 on d1,8,cisplatin 25 mg/m2 on dl-3 and dexamethasone 25 mg/m2 on dl-5,Arsenic oxide 10mg/d on dl-14.21 days for a cycle.Results: Of experimental group all response rate was 65.... |
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| Keywords: | Arsenic Trioxide GDP non-Hodgkin's lymphoma |
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