| 肾细胞癌NDRG-1和E-cadherin表达及其与临床病理因素、MVD及预后的关系 |
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| 引用本文： | 张冠军,王春宝,梁华,张学斌,王一理.肾细胞癌NDRG-1和E-cadherin表达及其与临床病理因素、MVD及预后的关系[J].现代肿瘤医学,2011,19(9):1697-1701. |
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| 作者姓名： | 张冠军 王春宝 梁华 张学斌 王一理 |
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| 作者单位： | 1. 西安交通大学医学院第一附属医院病理科,陕西,西安,710061
2. 西安交通大学癌症研究所,陕西,西安,710061 |
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| 基金项目： | 陕西省自然科学基金资助项目 |
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| 摘 要： | 目的:研究N-myc下游调节基因(NDRG-1)和上皮型钙粘素(E-cadherin)在肾细胞癌组织中的表达,探讨其与肾细胞癌临床病理因素、微血管密度(MVD)及预后的关系。方法:应用免疫组织化学SP法检测49例肾细胞癌组织及相对应的癌旁肾脏组织中NDRG-1、E-cadherin表达情况。结果:NDRG-1和E-cadherin在正常肾组织表达均高于肾细胞癌组织,差异有显著性(P<0.01);二者随肾细胞癌肿瘤组织学分级、临床分期增高表达减弱,有肾门淋巴结转移者表达低于无淋巴结转移者,E-cadherin表达降低还与肾盂浸润、肾静脉癌栓相关,差异均有显著性(P<0.05);NDRG-1和E-cadherin表达均与肾细胞癌MVD呈负相关性(P<0.05);NDRG-1和E-cadherin表达阴性病例术后存活时间均显著短于阳性病例(P=0.001);肾细胞癌组织中NDRG-1和E-cadherin表达无相关性(r=-0.253,P=0.086)。结论:NDRG-1和E-cadherin表达降低与肾细胞癌的浸润、转移及血管生成和生存时间密切相关,检测NDRG-1和E-cadherin可作为预测肾细胞癌浸润转移及预后有意义的指标。
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| 关 键 词： | 肾细胞癌 NDRG-1 E-cadherin MVD 免疫组织化学 |
Expression of NDRG-1 and E-cadherin in renal cell carcinoma and its relationship with MVD and prognosis |
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| ZHANG Guanjun,WANG Chunbao,LIANG Hua,ZHANG Xuebin,WANG Yili.Expression of NDRG-1 and E-cadherin in renal cell carcinoma and its relationship with MVD and prognosis[J].Journal of Modern Oncology,2011,19(9):1697-1701. |
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| Authors: | ZHANG Guanjun WANG Chunbao LIANG Hua ZHANG Xuebin WANG Yili |
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| Institution: | ZHANG Guanjun1,WANG Chunbao1,LIANG Hua1,ZHANG Xuebin1,WANG Yili21Department of Pathology,the First Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710061,China,2Cancer Institute of Xi'an Jiaotong University,China. |
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| Abstract: | Objective: To investigate clinicopathological,micro-angiogenesis and prognostic significance of the expression of N-myc down regulated gene 1(NDRG-1) and E-cadherin in renal cell carcinoma(RCC).Methods: High sensitive SP immunohistochemical method was used to detect the protein expressions of NDRG-1 and E-cadherin in 49 cases of renal cell cancer tissues and adjacent tissues.Results: The proportion of NDRG-1-expressing and E-cadherin-expressing tumor cells were significantly lower than that of normal cells(... |
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| Keywords: | renal cell carcinoma N-myc down regulated gene 1(NDRG-1) E-cadherin microvessel density(MVD) immunohistochemistry |
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