肿瘤化疗患者假丝酵母菌感染的研究

目的:研究住院肿瘤化疗患者中假丝酵母菌感染的分布及耐药性,为临床合理应用抗真菌药物提供依据。方法:用法国生物梅里埃公司提供的ID 32C做假丝酵母菌的鉴定,按CLSI要求,用ATBTM Fungus真菌药敏试验板条进行药敏试验。结果:假丝酵母菌属感染的主要真菌有5种,其中以白色假丝酵母菌最多,占55.3%;其他依次为热带假丝酵母菌占13.0%,光滑假丝酵母菌占12.6%,近平滑假丝酵母菌占8.9%,克柔假丝酵母菌占4.8%;假丝酵母菌耐药吡咯类较普遍,5-氟胞嘧啶次之(17.3%),对两性毒素B耐药(2.5%)的较少。结论:假丝酵母菌属感染主要由白色假丝酵母菌引起;假丝酵母菌对目前抗真菌药呈普遍耐药性,应联合足量用药。

Candida nosocodial infections in Tumor chemotherapy patients

Objective:To study the distribution of Candida infection and drug resistance in tumor chemotherapy patients and provide evidence for the clinical use of antifungal agents.Methods: Using ID 32C provided by the French company bioMérieux to identify Candida,according to CLSI requirements,antifungal susceptibility testing of Candida was performed by ATBTM FUNGUS Fungal Susceptibility strips.Results: There were five major species causing candida infection,of which C.albicans was the most,accounting for 55.3%;followed by C.tropicalis(13.0%),C.glabrata(12.6 %),C.parapsilosis(8.9 %),C.krusei(4.8 %).The resistance to antifungal drug of piromidic was common,resistance to 5-FC(17.3%)second,resistance to AMB(2.5%)less.Conclusion: Candida infection is caused by Candida albicans mainly;Candida is present antifungal drug resistance in general,sufficient amount of medication should be combined.