| 血清骨桥蛋白和CA125联合检测鉴别良恶性腹水 |
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| 引用本文： | 孙翠芬,董晓瑜,杨静华,魏晗. 血清骨桥蛋白和CA125联合检测鉴别良恶性腹水[J]. 现代肿瘤医学, 2011, 19(11): 2266-2268. DOI: 10.3969/j.issn.1672-4992.2011.11.43 |
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| 作者姓名： | 孙翠芬 董晓瑜 杨静华 魏晗 |
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| 作者单位： | 河北省胸科医院妇产科,河北,石家庄,050041 |
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| 基金项目： | 河北省医学科学重点课题计划，河北省卫生厅指令性项目 |
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| 摘 要： | 目的:探讨联合检测血清骨桥蛋白(OPN)和CA125在良恶性腹水中的诊断价值。方法:取39例恶性腹水患者、48例结核性腹水患者及40例健康妇女血清样品,分别用双抗体夹心酶联免疫吸附法(ELISA)及微粒子化学发光法测定其OPN和CA125水平,观察其在诊断良、恶性腹水时的敏感性和特异性。结果:恶性腹水患者血清OPN水平明显高于结核性腹水患者及健康妇女组。OPN检测恶性腹水的敏感度、特异度分别为84.6%、95.0%;CA125检测敏感度、特异度为76.9%、87.5%;联合检测敏感度97.4%、特异度为95.0%。联合检测OPN、CA125较单独检测OPN及CA125其敏感度高(P<0.05);特异度无明显差异。结论:OPN与CA125联合测定是鉴别卵巢癌和结核性腹水的有效方法,联合检测CA125可提高其临床应用价值。
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| 关 键 词： | 血清 腹水 骨桥蛋白(OPN) CA125 |
The predictive value of serum levels of OPN and CA125 on benign and malignant ascites |
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| SUN Cuifen,DONG Xiaoyu,YANG Jinghua,WEI Han. The predictive value of serum levels of OPN and CA125 on benign and malignant ascites[J]. Journal of Modern Oncology, 2011, 19(11): 2266-2268. DOI: 10.3969/j.issn.1672-4992.2011.11.43 |
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| Authors: | SUN Cuifen DONG Xiaoyu YANG Jinghua WEI Han |
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| Affiliation: | SUN Cuifen,DONG Xiaoyu,YANG Jinghua,WEI Han Department of Obstetrices and Gyncology Chest Hospital in Hebei Province,Hebei Shijiazhuang 050041,China |
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| Abstract: | Objective:To investigate the value of combined detection of serum osteopontin(OPN),and CA125 in the diagnosis and treatment of benign and malignant ascites.Methods: Thirty nine cases of malignant ascites,48 cases of tuberculous ascites and serum samples of 40 healthy women were detected,by double antibody sandwich enzyme-linked immunosorbent assay(ELISA)and chemiluminescent for OPN and CA125 levels.Results: In malignant ascites serum OPN levels were significantly higher than that of tuberculous ascites and ... |
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| Keywords: | serum ascites osteopontin(OPN) CA125 |
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