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| 粉防己碱对宫颈癌细胞周期影响及其机制研究 | |
| 引用本文： | 慕建宁,马小红,李玢,邓卓,韩晓兵,朱克修. 粉防己碱对宫颈癌细胞周期影响及其机制研究[J]. 现代肿瘤医学, 2011, 19(11): 2191-2193. DOI: 10.3969/j.issn.1672-4992.2011.11.16 |
| 作者姓名： | 慕建宁 马小红 李玢 邓卓 韩晓兵 朱克修 |
| 作者单位： | 1. 西安交通大学医学院第一附属医院妇产科,陕西,西安,710061;西安高新医院妇科,陕西,西安,710075 2. 西安高新医院妇科,陕西,西安,710075 3. 西安交通大学医学院第一附属医院妇产科,陕西,西安,710061 |
| 摘 要： | 目的:研究粉防己碱对HeLa细胞的抗肿瘤作用,并探讨其分子机制。方法:用MTT法检测粉防己碱对HeLa细胞增殖的影响。流式细胞仪检测细胞周期分布。Western blot法检测粉防己碱处理前后HeLa细胞中Chk1/2蛋白表达情况。结果:粉防己碱对HeLa细胞的增殖抑制作用呈时间浓度相关性并可引起S期阻滞,粉防己碱作用后HeLa细胞Chk1/2蛋白的表达较对照组减少。可能与细胞周期阻滞的分子机制相关。结论:粉防己碱可以抑制宫颈癌HeLa的增殖,其诱导S期阻滞的分子机制可能与Chk1/2蛋白相关。 |
| 关 键 词： | 粉防己碱 HeLa细胞株 细胞周期 |
Effects of tetrandrine on cell cycle regulatory processes of HeLa cells and their mechanisms |
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| Mu Jianning,MA Xiaohong,LI Bin,DENG Zhuo,HAN Xiaobing,ZHU Kexiu. Effects of tetrandrine on cell cycle regulatory processes of HeLa cells and their mechanisms[J]. Journal of Modern Oncology, 2011, 19(11): 2191-2193. DOI: 10.3969/j.issn.1672-4992.2011.11.16 | |
| Authors: | Mu Jianning MA Xiaohong LI Bin DENG Zhuo HAN Xiaobing ZHU Kexiu |
| Affiliation: | Mu Jianning1,2,MA Xiaohong2,LI Bin1,DENG Zhuo1,HAN Xiaobing1,ZHU Kexiu1 1Department of Obstetrics & Gynecology,First Affiliated Hospital,Medical College,Xi'an Jiaotong University,Xi'an 710061,China,2Department of Gynecology,Xi'an Gaoxin Hospital,Xi'an 710075 |
| Abstract: | Objective:To investigate the anticancer activities of tetrandrine on HeLa cells and the molecular mechanisms.Methods: The proliferation inhibitory rates of HeLa cells induced by tetrandrine in different concentrations and time were measured by MTT assays.Cell cycle was analyzed by flow cytometry.The protein expression of Chk1/2 of HeLa cells was detected by Western blot.Results: Tetrandrine inhibited the proliferation of HeLa cells in dosage and time dependent manner.Tetrandrine induced S phase arrest of He... |
| Keywords: | tetrandrine HeLa cells cell cycle |
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