| 痰热清注射液对流感病毒FM1感染小鼠的保护作用 |
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| 引用本文： | 郑金粟,顾立刚,李澎涛,邱泽计,李根茂.痰热清注射液对流感病毒FM1感染小鼠的保护作用[J].中国中医药信息杂志,2006,13(12):39-41. |
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| 作者姓名： | 郑金粟 顾立刚 李澎涛 邱泽计 李根茂 |
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| 作者单位： | 北京中医药大学基础医学院,中医药抗病毒教育部重点实验室,北京,100029 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的研究痰热清注射液对流感病毒亚甲型鼠肺适应株(FM1)感染小鼠的保护作用。方法观察痰热清注射液对流感病毒FM1感染小鼠的死亡保护作用,以及肺指数和肺组织病理形态学变化,同时检测肺组织匀浆中流感病毒血凝滴度。结果痰热清注射液治疗组对流感病毒FM1感染小鼠具有明显的保护作用,死亡保护率与模型组小鼠比较,差异显著(P<0.05);肺组织病理形态学观察发现,痰热清注射液治疗组肺部炎症反应较模型组有显著改善。另外,痰热清注射液对肺组织匀浆中流感病毒血凝滴度具有明显的抑制作用。结论痰热清注射液(4mL/kg)对流感病毒FM1感染小鼠具有明显的保护作用。这种保护作用与痰热清注射液在体内抑制流感病毒增殖、减轻肺部炎症反应有关。
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| 关 键 词： | 痰热清注射液 流感病毒亚甲型鼠肺适应株 肺指数 |
| 文章编号： | 1005-5304（2006）12-0039-03 |
| 收稿时间： | 2006-06-13 |
| 修稿时间： | 2006年6月13日 |
Protective Effect of Tanreqing Injection on the Mice Infected with Influenza Virus FM1 |
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| ZHENG Jin-su, GU Li-gang, LI Peng-tao, et al.Protective Effect of Tanreqing Injection on the Mice Infected with Influenza Virus FM1[J].Chinese Journal of Information on Traditional Chinese Medicine,2006,13(12):39-41. |
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| Authors: | ZHENG Jin-su GU Li-gang LI Peng-tao |
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| Institution: | School of Basic Medical Science, Beijing University of TCM; Key Laboratory of TCM1, Ministry of Education, Beijing 100029, China |
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| Abstract: | Objective To investigate the protective effect of Tanreqing injection on the mice infected with influenza virus FM 1 . Methods The experiment includes protection of Tanreqing injection to the mice infected with influenza virus FM1, and effect of Tanreqing injection to the viral titers, pathology and lung index of mice with influenza virus FM 1 . Results Tanreqing injection can reduce the mortality of the mice with influenza virus FM 1 infected. And Tanreqing injection can improve viral titers, pathology, and lung index of the mice infected with influenza virus FM1. Conclusions Tanreqing injection can protect the mice infected with influenza virus FM 1 by resisting the influenza virus and meliorating the lung pathology of the mice infected with influenza virus FM 1 . |
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| Keywords: | Tanreqing injection influenza virus FM 1 lung index |
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