慢性阻塞性肺疾病急性加重与环境因素的相关性研究

[目的] 探讨不同程度肺功能损害的慢性阻塞性肺疾病（COPD）急性加重与大气质量、气温等环境因素的关系。[方法] 收集2004年1月1日-2009年7月31日，上海一所中心医院收住入院的慢性阻塞性肺疾病急性加重的病例，按入院后肺功能检查结果分成轻度、中度、重度3组。分析每组每日入院人数与入院当天（d₀）、前1天（d_-1）、前3天（d_-3）、前6天（d_-6）的大气污染物浓度、气温之间的相关性。[结果] 肺功能重度损害COPD组每日入院人数与大气质量因素均呈现一定的正相关。与最高、最低气温呈一定的负相关。肺功能中度损害COPD组每日入院人数与入院前3天PM10的API值呈正相关，与最低气温呈负相关。肺功能轻度损害COPD组每日入院人数与入院当天的SO₂的API值呈正相关，与最低气温呈负相关。[结论] 慢性阻塞性肺疾病急性加重的发生与大气质量、气温存在一定的相关性，尤其是对于肺功能重度损害的COPD病人。提示大气污染、气温降低是慢性阻塞性肺病急性加重的重要诱因。

Correlation of acute exacerbation of chronic obstructive pulmonary disease with environmental factors

[Objective] To explore the relationship of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with environmental factors such as air quality and temperature. [Methods] From January 2004 to July 2009,hospitalized patients of AECOPD were collected from central hospitals.According to the result of pulmonary function test,the cases were divided into three groups: mild,moderate and severe ones.The analyses were made between the daily number of admitted patients in each group and the density of a...