E-钙粘蛋白在肿瘤中的表达与分化转移的关系

目的　研究Ｅ钙粘蛋白（Ｅｃａｄｈｅｒｉｎ）在胃癌、结直肠癌、宫颈癌、乳腺癌中的表达与肿瘤分化程度，侵袭转移等生物行为的关系及在４种癌症中表达的相互关系。方法　用免疫组织化学ＡＢＣ法检测２０例胃癌、２１例结直肠癌、２０例宫颈癌、２０例乳腺癌石蜡标本Ｅ钙粘蛋白的表达水平。结果　Ｅ钙粘蛋白在４种肿瘤中的表达有一定的相似，即癌组织较癌旁组织的表达水平低，高中分化肿瘤比低分化肿瘤表达水平高。Ｅ钙粘蛋白在不同转移情况肿瘤中的表达结果差异不明显。结论　Ｅ钙粘蛋白癌旁组织中的表达明显高于癌组织，并与分化程度有直接关系；与转移的关系比较复杂，有待于进一步研究。Ｅ钙粘蛋白在４种肿瘤中的表达有一致性，所以Ｅ钙粘蛋白免疫组织化学研究有一定的临床病理价值。

E-Cadherin Expression in Carcinoma and Relation to Differentiation and Metastasis

Purpose To obtain the pattern and extent of reactivity has be correlated with clinicopathological data including tumor type,grade,and hymph node status,expression of E cadherin. Methods Expression of E cadherin has been examined in 20 gastric carcinomas;21 colorectal carcinomas;20 uterocervical carcinomas and 20 breast carcinomas using an immunohistochemical technique. Results There are similar pattern among four kinds of cancer.Tumors with a decrease in E cadherin occurred significantly more frequently in poor differentiated carcinomas.There was association between membrane levels of E cadherin and the pre sence of lymph node metastasis but the difference is not significant. Results There are similar pattern among four kinds of cancer.Tumors with a decrease in E cadherin occurred significantly more frequently in poor differentiated carcinomas.There was association between membrane levels of E cadherin and the pre sence of lymph node metastasis but the difference is not significant. Conclusions E cadherin expression of the noncancerous areas ins highter than that of the cancerous areas.The decreased E cadherin expression correlates with dedifferentiation.The relation between the E cadherin expression and the metastasis is complex and need much more research.There are similar pattern among four types of cancer.For that,immunohistochemical study of E cadherin may have clinicopathologic value for patients with cancer.