| 外周血循环DNA在肝细胞癌早期诊治的研究进展 |
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| 引用本文： | 胡捷,周俭,王征,樊嘉. 外周血循环DNA在肝细胞癌早期诊治的研究进展[J]. 复旦学报(医学版), 2009, 36(6): 776-778. DOI: |
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| 作者姓名： | 胡捷 周俭 王征 樊嘉 |
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| 作者单位： | 复旦大学附属中山医院肝癌研究所肝外科，上海200032 |
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| 基金项目： | 国家自然科学基金项目 |
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| 摘 要： | 循环DNA是存在于血浆/血清中的游离DNA。已有研究证实肿瘤患者循环DNA来源于肿瘤细胞。因此，检测肿瘤患者循环DNA质和量的改变对肿瘤的早期诊断和预后分析具有较大价值。循环DNA检测具有微创性、标本获取方便、可连续动态检测等优点，是一种极具前景的肿瘤标志物。有关肝癌患者循环DNA的研究不多，本文就循环DNA检测在肝癌诊断和预后分析中的研究进展做一综述。
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| 关 键 词： | 循环DNA 肝细胞癌 诊断 预后 |
| 收稿时间： | 2008-11-17 |
The advances in the study of circulating DNA in early diagnosis and treatment for hepatocellular carcinoma |
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| HU Jie,ZHOU Jian,WANG Zheng,FAN Jia. The advances in the study of circulating DNA in early diagnosis and treatment for hepatocellular carcinoma[J]. Fudan University Journal of Medical Sciences, 2009, 36(6): 776-778. DOI: |
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| Authors: | HU Jie ZHOU Jian WANG Zheng FAN Jia |
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| Affiliation: | Department Of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China |
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| Abstract: | Circulating DNA is cell-free DNA existing in plasma or serum. It has already been verified that circulating DNA of cancer patients is derived from tumor cells. Therefore, it is of great value to detect the changes in the quantity and quality of the circulating DNA in cancer patients for early diagnosis and prognosis. The advantages of the detection of circulating DNA such as micro-trauma, convenient access to samples, possibility of continuous and dynamic monitoring, make it a promising tumor mark. This review recapitulates the application of circulating DNA analysis in hepatocellular carcinoma patients for diagnosis and prognosis. |
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| Keywords: | circulating DNA hepatocellular carcinoma diagnosis prognosis |
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