高强度聚焦超声治疗肝癌的近期疗效分析

目的探讨高强度聚焦超声(HIFU)治疗肝癌的近期疗效。方法44例肝癌患者通过全身麻醉、超声肿瘤定位进行HIFU治疗,观察HIFU治疗前后临床症状以及肝功能、AFP、MRI的变化。结果HIFU治疗后患者的临床症状缓解率为87.5％(28/32),其中3例患者少量腹水自行消失。治疗前患者的ALT为(79.73±12.31)U/L,AST为(103.47±24.55)U/L;治疗后ALT、AST降至正常水平者分别占84.6％(22/26)和73.5％(25/34),AFP降低超过原数值50％者占64.3％(18/28),MRI显示肿瘤治疗区已凝固性坏死,肿瘤血供减少或消失。结论HIFU对肝癌患者的治疗是确切有效的,可成为肝癌无创局部治疗的新方法。

High intensity focused ultrasound for liver cancer

Objective To evaluate the effect of high intensity focused ultrasound (HIFU) for liver cancer. Methods HIFU treatment was performed in 44 liver cancer patients under general anesthesia and ultrasound positioning. Before and after HIFU treatment, the clinical symptoms, liver functional tests, AFP and MRI were evaluated. Results After HIFU treatment, the remission rate of clinical symptoms was 87.5% (287 32), with the scanty ascites in 3 patients disappeared. ALT (79.73 + 12.31 U/L) and AST(103.47 + 24.55 U/ L) before HIFU were reduced to normal in 84.6%(22/26) and 73.5%(25/34) patients. AFP in 64.3%(18/ 28) patients decreased > 50% of the original value. After HIFU, MRI showed coagulative necrosis and blood supply reduction or disappearance of tumor in the target region. Conclusion HIFU treatment pocesses good effect on liver cancer, which will offer a considerable weight in noninvasive local treatment of hepatic tumor.