| 血管内皮生长因子在大肠癌中的表达及临床意义 |
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| 引用本文： | 何志国,冯家成,孙达春,扬欢珍,莫海山.血管内皮生长因子在大肠癌中的表达及临床意义[J].肿瘤研究与临床,2003,15(4):228-230. |
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| 作者姓名： | 何志国 冯家成 孙达春 扬欢珍 莫海山 |
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| 作者单位： | 1. 中山大学附属第五医院
2. 珠海市人民医院,广东,珠海,519000 |
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| 摘 要： | 目的研究肿瘤生长因子(VEGF)和肿瘤微血管密度(MVD)的表达水平在大肠癌中的临床意义.方法对86例手术切除的大肠癌患者的临床病理资料进行研究,并采用免疫组化方法检测VEGF蛋白和MVD在大肠癌的表达水平.结果VEGF表达阳性率为62.8%.MVD和VEGF表达的程度明显相关.VEGF的阳性表达与组织学类型及肿瘤位置无显著相关(P＞0.05),而与淋巴结转移、肝肺等远处转移及浸润深度有明显相关性(P＜0.05).结论VEGF是由肿瘤细胞所分泌的,并在大肠癌的生长和转移过程中发挥重要的作用.
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| 关 键 词： | 大肠癌 血管内皮生长因子 微血管密度 肿瘤转移 |
| 文章编号： | 1006-9801(2003)04-0228-03 |
| 修稿时间： | 2003年1月6日 |
CLINCAL SIGNIFICANCE OF VEGF EXPRESSION IN COLORECTAL CARCINOMA |
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| Abstract: | Objective : To evaluate the clinico pathological significance of intratumoral vascular endothelial growth factor ( VEGF ) and microvessel density ( MVD ) expression in human colorectal carcinoma. Methods : A study including 86 postoperative colorectal carcinoma patients was done,and expression level of VEGF and the MVD were examined with immunohistochemical method. Results : The expression rate of VEGF was 62.8 % . The MVD was significantly related with the expression level of VEGF . VEGF was significantly related with the lymph node and live metastasis,infiltrative depth ( P <0.05 ) , but it was not significantly related with histology type and tumor position ( P >0.05).Conclusion:VEGF is excreted by tumor cells, and had an important effect in course of colorectal carcinoma growth and metastasis. |
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| Keywords: | Colorectal carcinoma Vascular endothelial growth factor (VEGF) Microvessel density (MVD) Neoplasm metastasis |
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