| LIGHT-HVEM—BTLA共信号分子的研究进展 |
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| 引用本文： | 汪怀周,沈茜.LIGHT-HVEM—BTLA共信号分子的研究进展[J].国际免疫学杂志,2009,32(1):34-38. |
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| 作者姓名： | 汪怀周 沈茜 |
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| 作者单位： | 第二军医大学附属长海医院实验诊断科,上海,200433 |
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| 摘 要： | BTLA是新近发现的一个CD28超家族共抑制分子，它的配体不是B7家族成员而是TNF受体超家族成员HVEM。HVEM同时还存在一个TNF超家族的配体，即T细胞上可诱导表达的与HSV的糖蛋白D竞争结合HVEM的淋巴毒素类似物（LIGHT）。HVEM可以作为一个分子开关，通过结合LIGHT或BTLA7E免疫调节中发挥不同的作用。
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| 关 键 词： | BTLA HVEM LIGHT 淋巴细胞活化 |
Advancement in LIGHT-HVEM-BTLA pathway |
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| WANG Huai-zhou,SHEN Qian.Advancement in LIGHT-HVEM-BTLA pathway[J].International Journal of Immunology,2009,32(1):34-38. |
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| Authors: | WANG Huai-zhou SHEN Qian |
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| Institution: | (Department of Laboratory Diagnosis, Changhai Hospital, The Second Military Medical University,200433 Shanghai, China) |
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| Abstract: | B and T lymphocyte attenuator ( BTLA),a most recently identified inhibitory receptor of the CD28 superfamily,is unusual in that its ligand is not one of the classic B7 family members,but a tumor necrosis factor receptor (TNFR) superfamily member,herpes virus entry mediator (HVEM).HVEM also has another ligand,lymphotoxin-like,exhibits inducible expression,and competes with HSV glycoprotein D for HVEM ,a receptor expressed by T lymphocytes( LIGHT),a member of the TNF superfamily.HVEM was considered as a molecular switch because it played different role in immune regulation by propagating LIGHT or BTLA. |
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| Keywords: | BTLA HVEM LIGHT |
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