Survival in node-positive early oral squamous cell carcinoma: sentinel node biopsy versus elective neck dissection |
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| Affiliation: | 1. Greater Glasgow & Clyde Health Board, United Kingdom;2. College of Medical, Veterinary & Life Sciences, University of Glasgow, G12 8QQ, United Kingdom;3. Independent Software Engineer, United Kingdom;4. NHS Ayrshire and Arran Crosshouse Hospital, United Kingdom;1. Department of Oral & Maxillofacial surgery, All India Institute of Medical Sciences, New Delhi, India;2. Department of Physiology, All India Institute of Medical Sciences, New Delhi, India;1. Division of Oral and Maxillofacial Surgery, Federal University of Ceará, Campus Sobral, Sobral, Brazil. Division of Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil;2. Division of Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil;3. Division of Oral and Maxillofacial Surgery, Leão Sampaio Universitary Center, Cariri, Ceará, Brazil. Division of Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil;4. Division of Oral and Maxillofacial Surgery, Federal University of Ceará, Fortaleza, Brazil. Division of Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil;5. Division of Oral Radiology, Federal University of Ceará, Fortaleza, Brazil. Division of Oral and Maxillofacial Surgery, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil;1. Department of Oral and Maxillofacial Surgery, University Hospital Galway, Galway, Ireland;2. Department of Histopathology, University Hospital Galway, Galway, Ireland;3. Department of Histopathology, University Hospital Limerick, Limerick, Ireland;4. Department of Histopathology, Children’s Health Ireland at Crumlin, Dublin, Ireland;1. Leeds Teaching Hospitals Trust, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, United Kingdom;2. University of Leeds, Worsley Building, University of Leeds, Woodhouse, Leeds LS2 9JT, United Kingdom |
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| Abstract: | Patients undergoing sentinel node biopsy (SLNB) for early oral squamous cell carcinoma (OSCC) who harbour occult metastases (pN+ve) may be at greater risk of mortality due to prolonged overall treatment times than those identified as pN+ve on elective neck dissection (ELND). A retrospective comparative survival analysis was therefore undertaken to test this hypothesis. Patients were identified from the South Glasgow multidisciplinary team (MDT) database. Group 1 comprised 38 patients identified as pN+ve, or who were false negative, on sentinel lymph node biopsy (SLNB). Group 2 comprised 146 patients staged pN+ve on ELND. The groups were compared with the Kaplan Meier method and Cox proportional hazards model. In addition, a matched-pair analysis was performed. A unique and specifically designed algorithm was deployed to optimise the pairings. No difference in disease-specific or overall survival was found between the groups. Patients undergoing SLNB as the initial neck staging modality in early OSCC and are identified as pN+ve do not appear to be at a survival disadvantage compared with those staged with ELND. |
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| Keywords: | Oral cavity Squamous cell carcinoma Sentinel lymph node biopsy |
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