叉头框蛋白C2、淋巴管内皮透明质酸受体-1的表达与皮肤鳞状细胞癌生物学特性的相关性

目的 探讨叉头框蛋白C2(FoxC2)和淋巴管内皮透明质酸受体-1(LYVE-1)与皮肤鳞状细胞癌生物学特性的相关性。方法 收集2013年10月至2021年1月在江苏大学附属医院收治的44例原发性皮肤鳞状细胞癌病人，采用免疫组织化学染色检测FoxC2、LYVE-1的表达情况，LYVE-1的表达情况用微淋巴管密度（MLVD）表示。结果 FoxC2在皮肤鳞状细胞癌淋巴结转移组、中低分化组的高表达率88.88%(8/9)、88.88%(16/18)]明显高于无淋巴结转移组、高分化组42.85%(15/35)、26.92%(7/26)]（均P<0.05）。LYVE-1在皮肤鳞状细胞癌淋巴结转移组、中低分化组的表达（13.31±6.23、14.28±4.42）明显高于无淋巴结转移组、高分化组（8.67±4.33、6.39±2.09）（均P<0.05）。FoxC2、LYVE-1的表达情况与病人的年龄、性别、肿瘤长径无关（均P>0.05）。FoxC2与LYVE-1的表达呈正相关（r=0.55,P<0.01）结论 FoxC2及LYVE-1参与调控皮肤鳞状细胞癌生长及淋巴结转...

Correlation of the expressions of FoxC2 and LYVE-1 with biological characteristics of cutaneous squamous cell carcinoma

Objective To investigate the relationship between forkhead box protein C2 (FoxC2) and lymphatic vessel endothelial re-ceptor 1 (LYVE-1) and the biological characteristics of cutaneous squamous cell carcinoma.Methods A total of 44 patients with pri-mary skin squamous cell carcinoma admitted to The Affiliated Hospital of Jiangsu University in Zhenjiang, Jiangsu Province from Octo-ber 2013 to January 2021 were collected. Immunohistochemical method was used to detect the expressions of FoxC2 and LYVE-1, and the expression of LYVE-1 was indicated by the microlymphatic vessel density (MLVD).Results The high expression rates of FoxC2 in the group with lymph node metastasis and the group with medium-low differentiation 88.88% (8/9), 88.88% (16/18)] were significantly higher than those in the group without lymph node metastasis and the group with high differentiation 42.85% (15/35), 26.92% (7/26)](all P<0.05). The expression levels of LYVE-1 in the group with lymph node metastasis and the group with medium-low differentiation(13.31±6.23), (14.28±4.42)] was significantly higher than those in the group without lymph node metastasis and the group with high dif-ferentiation (8.67±4.33), (6.39±2.09)] (all P<0.05). The expressions of FoxC2 and LYVE-1 were not related to age, gender and tumor size (all P>0.05). The expression of FoxC2 was positively correlated with the expression of LYVE-1 (r=0.55, P<0.01).Conclusions FoxC2 and LYVE-1 were involved in regulating the growth and lymph node metastasis of cutaneous squamous cell carcinoma.These re-sults provide a new strategy for clinical diagnosis and treatment of cutaneous squamous cell carcinoma.