Antibody titers among healthcare workers for coronavirus disease 2019 at 6 months after BNT162b2 vaccination |
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Affiliation: | 1. Departments of Respiratory Medicine, Itai 1696, Kumagaya City, Saitama 360-0105, Japan;2. Clinical Laboratory, Itai 1696, Kumagaya City, Saitama 360-0105, Japan;3. Infection Control, Saitama Cardiovascular and Respiratory Center, Itai 1696, Kumagaya City, Saitama 360-0105, Japan |
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Abstract: | BackgroundAntibody levels decrease substantially at 6 months after the BNT162b2 vaccine. The factors influencing titer of antibodies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among healthcare workers for coronavirus disease 2019 (COVID-19) is unclear.MethodsWe conducted a 6-month longitudinal prospective study in Japanese healthcare workers in a tertiary care hospital for COVID-19. Participants in the study were tested for the presence of anti-spike protein (SP) IgG antibodies before and at 1 and 6 months after the last vaccination dose.ResultsAmong 1076 healthcare workers, 794 received the vaccine, and 469 entered the study. Five were infected with SARS-CoV-2 (none among COVID-19 section workers) by the end of the study and 451 participants were finally analyzed (mean age, 42.5 years; 27.3 % male; 18.8 % COVID-19 section workers). Median SP IgG index values were 0.0, 44.4, and 5.5 before and at 1 and 6 months after the last dose, respectively. Regression analysis revealed a negative correlation of SP IgG antibody levels with age (P < 0.0001), and higher levels in COVID-19 section workers (P = 0.0185) and in females (P = 0.0201).ConclusionIn healthcare workers at a COVID-19 hospital, IgG antibody titer was substantially lower at 6 months after receipt of the last dose of the BNT162b2 vaccine compared with that 1 month after the last dose, but was better preserved among younger participants, COVID-19 section workers and females. |
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Keywords: | Coronavirus disease-2019 Vaccination Healthcare workers Side effects Antibody titre COVID-19" },{" #name" :" keyword" ," $" :{" id" :" k0035" }," $$" :[{" #name" :" text" ," _" :" coronavirus disease 2019 SARS-CoV-2" },{" #name" :" keyword" ," $" :{" id" :" k0045" }," $$" :[{" #name" :" text" ," _" :" severe acute respiratory syndrome coronavirus-2 SP" },{" #name" :" keyword" ," $" :{" id" :" k0055" }," $$" :[{" #name" :" text" ," _" :" spike protein NP" },{" #name" :" keyword" ," $" :{" id" :" k0065" }," $$" :[{" #name" :" text" ," _" :" nucleocapsid |
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