Prognostic significance of dysplasia associated with oral squamous cell carcinoma in patients undergoing surgery with curative intent |
| |
| Affiliation: | 1. Oral and Maxillofacial Surgery Department, Queen Elizabeth Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland;2. Glasgow Medical School, University Avenue, Glasgow G12 8QQ, Scotland;1. Department of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, Oral Diseases Laboratory of Liaoning, China Medical University, Shenyang, China;2. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ibb University, Ibb, Yemen;3. Jibla University for Medical Sciences, Jibla Hospital, Ibb, Yemen;4. Department of Oral and Maxillofacial Surgery, Lanzhou University Second Hospital, Lanzhou, China;1. Head and Neck Academic Centre, University College London, Gower St, Bloomsbury, London WC1E 6BT, United Kingdom;2. Department of Oral and Maxillofacial Head and Neck Surgery, University College Hospital London, 235 Euston Rd, Bloomsbury, London NW1 2BU, United Kingdom;3. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;1. Oral and Maxillofacial Surgery Unit, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK;2. Department of Colorectal and General Surgery, The Royal Wolverhampton NHS Trust, New Cross Hospital, Wolverhampton WV10 0QP, UK;3. Department of Orthopaedics, Great Ormond St Hospital for Children, London WC1N 3JH, UK |
| |
| Abstract: | The aim of this study was to evaluate the prognostic significance of dysplasia in patients undergoing primary surgery with curative intent in the treatment of oral squamous cell carcinoma (OSCC). This study specifically aimed to demonstrate the effect of dysplasia on local recurrence, disease specific survival (DSS) and overall survival (OS). Data collection for 833 patients with OSCC undergoing treatment for curative intent was undertaken retrospectively for the period of February 2006 to May 2020. Analysis of any association between known clinicopathological prognostic categorical variables with respect to dysplasia was undertaken using the chi squared test. A Kaplan-Meier analysis was performed to demonstrate the impact of dysplasia on DSS and OS, and Cox’s proportional-hazards model deployed to obtain hazard ratios associated with dysplasia and the outcomes of interest. Dysplasia was statistically significant in predicting disease specific and overall survival in patients undergoing primary surgery for OSCC (DSS p<0.001, HR 0.577; 95%CI 0.428 to 0.777), OS p<0.001 HR 0.691; 95%CI 0.562 to 0.850) with the absence of dysplasia predicting poorer outcomes. The absence of dysplasia correlated with pathological higher T and N stage, increased categorised depth of tumour invasion, non-cohesive invasive front, lymphovascular invasion, perineural invasion, extranodal extension and increased modified Glasgow Prognostic Score. No significant prognostic relationship was attributable to the presence of dysplasia at a surgical margin. The absence of dysplasia appeared to be a significant independent prognostic indicator for patients with OSCC. The presence or absence of dysplasia may provide a heuristic means of stratifying OSCC primary lesions in terms of disease hostility. |
| |
| Keywords: | Oral Squamous Cell Carcinoma Dysplasia Oral cavity Prognostication |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
