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Transport distraction osteogenesis compared with autogenous grafts for ramus-condyle unit reconstruction in temporomandibular joint ankylosis: a systematic review and meta-analysis
Affiliation:1. Department of Oral and Maxillofacial Surgery, TU Dental Teaching Hospital, MMC, Institute of Medicine, Kathmandu, Nepal;2. Oral and Maxillofacial Surgery, Private Practice, New Delhi, India;3. Ek Ek Paila Foundation, Kathmandu, Nepal;4. Department of Oral Biology, Chitwan Medical College, Bharatpur, Nepal;5. Department of Oral and Maxillofacial Surgery, CDER, AIIMS, New Delhi, India;1. Department of Plastic Surgery, St Thomas’ Hospital, London, United Kingdom;2. Department of Oral and Maxillofacial Surgery, The Queen Victoria Hospital, East Grinstead, United Kingdom;3. Foundation Year 1 Doctor, Department of General Surgery, University Hospital of North Tees Newcastle, United Kingdom;4. Honorary Professor of Surgery, Consultant Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, United Kingdom;1. GSR Hospital, Hyderabad, Telangana, India;2. Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands;3. Sri Sai College of Dental Surgery, Department of Oral and Maxillofacial Surgery, Vikarabad, Telangana, India;4. Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands;5. Dept. Of Cranio-maxillofacial Surgery, AIIMS, Rishikesh, Uttarakhand, India;1. Research Program on Integrated Dental Sciences, Faculty of Dentistry of the University of Cuiaba – UNIC, Cuiaba, Mato Grosso, Brazil;2. Department of Oral and Maxillofacial Surgery, General Hospital of Cuiaba, Cuiaba, Mato Grosso, Brazil;3. Research Program on Integrated Dental Sciences, Faculty of Dentistry of the University of Cuiaba – UNIC, Cuiaba, Mato Grosso, Brazil;4. Department of Oral and Maxillofacial Surgery, Traumatology and Prosthesis, Faculty of Dentistry of the University of São Paulo – USP, Sao Paulo, Sao Paulo, Brazil;5. Department of Stomatology, Faculty of Dentistry of the University of São Paulo – USP, Sao Paulo, Sao Paulo, Brazil;6. Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil;7. Department of Oral and Maxillofacial Surgery, University of Illinois – UIC, Chicago, IL, United States;8. Research Program on Integrated Dental Sciences, Faculty of Dentistry of the University of Cuiaba – UNIC, Cuiaba, Mato Grosso, Brazil
Abstract:This systematic review was planned to assess the clinical outcomes of transport distraction osteogenesis (TDO) compared with autogenous grafts for reconstruction of the ramus condyle unit (RCU). We searched Medline, Embase, Cochrane Library, Clinicaltrial.gov, and the references of included trials. The primary outcome was maximal incisal opening (MIO). Of the 148 studies retrieved, five were included (TDO = 49, autogenous grafts =123). The mean difference in MIO between TDO and autogenous graft RCU reconstruction, based on the random-effects model was 1.28 mm (95% CI 0.167 to 2.403) in favour of TDO. Re-ankyosis was observed in four cases in the costochondral graft group and none in the TDO group. Reconstruction of the RCU using TDO is comparable to autogenous grafts after the release of TMJ ankylosis, though the evidence is weak considering the small number of trials, high risk of bias, and absence of long-term results.
Keywords:TMJ ankylosis  transport distraction osteogenesis  RCU reconstruction  systematic review  meta-analysis  evidence synthesis  RCU"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Ramus condyle unit  DO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Distraction osteogenesis  TDO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Transport distraction osteogenesis  TMJA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Temporomandibular joint ankylosis  CCG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0080"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Costochondral graft  MIO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0090"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Maximal incisal opening.
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