Association between COVID-19 vaccination status,time elapsed since the last vaccine dose,morbidity, and absenteeism among healthcare personnel: A prospective,multicenter study |
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| Institution: | 1. Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece;2. Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece;3. First Department of Pediatrics, University of Athens, Aghia Sophia Children’s Hospital, Athens, Greece;4. Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States;5. Department of Infection Control, 251 Hellenic Air Force General Hospital, Athens, Greece;6. Paediatric Department, 251 Air Force General Hospital, Athens, Greece;7. Infection Control Committee, Laiko General Hospital, Athens, Greece;8. Infection Control Committee, University Hospital of Alexandroupolis, Alexandroupolis, Greece;9. COVID-19 Intensive Care Unit, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece;10. Operating Rooms, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece;11. Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece;12. Faculty of Social and Political Sciences, University of Peloponnese, Corinth, Greece;13. Health Policy Institute, Athens, Greece;14. Infection Control Committee, Aghia Sofia Children''s Hospital, Athens, Greece;15. Medical Directorate, Hellenic National Defence General Staff, Athens, Greece |
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| Abstract: | AimWe assessed the impact of COVID-19 vaccination status and time elapsed since the last vaccine dose on morbidity and absenteeism among healthcare personnel (HCP) in the context of a mandatory vaccination policy.MethodsWe followed 7592 HCP from November 15, 2021 through April 17, 2022. Full COVID-19 vaccination was defined as a primary vaccination series plus a booster dose at least six months later.ResultsThere were 6496 (85.6 %) fully vaccinated, 953 (12.5 %) not fully vaccinated, and 143 (1.9 %) unvaccinated HCP. A total of 2182 absenteeism episodes occurred. Of 2088 absenteeism episodes among vaccinated HCP with known vaccination status, 1971 (94.4 %) concerned fully vaccinated and 117 (5.6 %) not fully vaccinated. Fully vaccinated HCP had 1.6 fewer days of absence compared to those not fully vaccinated (8.1 versus 9.7; p-value < 0.001). Multivariable regression analyses showed that full vaccination was associated with shorter absenteeism compared to not full vaccination (OR: 0.56; 95 % CI: 0.36–0.87; p-value = 0.01). Compared to a history of ≤ 17.1 weeks since the last dose, a history of > 17.1 weeks since the last dose was associated with longer absenteeism (OR: 1.22, 95 % CI:1.02–1.46; p-value = 0.026) and increased risk for febrile episode (OR: 1.33; 95 % CI: 1.09–1.63; p-value = 0.004), influenza-like illness (OR: 1.53, 95 % CI: 1.02–2.30; p-value = 0.038), and COVID-19 (OR: 1.72; 95 % CI: 1.24–2.39; p-value = 0.001).ConclusionsThe COVID-19 pandemic continues to impose a considerable impact on HCP. The administration of a vaccine dose in less than four months before significantly protected against COVID-19 and absenteeism duration, irrespective of COVID-19 vaccination status. Defining the optimal timing of boosters is imperative. |
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| Keywords: | COVID-19 vaccination Booster Healthcare personnel Morbidity Absenteeism |
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