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Use of a proline-specific endopeptidase to reintroduce gluten in patients with non-coeliac gluten sensitivity: A randomized trial
Affiliation:1. Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;2. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;3. Department of Nutrition, School of Medicine, University of Chile, Santiago, Chile;4. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy;5. Human Advanced Microbiome Project-HMAP, Milan, Italy;6. Human Nutrition, Institute of Nutrition and Food Technology, INTA, University of Chile, Santiago, Chile;1. School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China;2. Department of Chronic Disease Control and Prevention, Changshu Center for Disease Control and Prevention, Changshu, China;3. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, Suzhou, China;1. Division of Geriatric Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;2. The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College, Hanover, NH, USA;3. Division of Internal Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;4. Division of General Medicine and Clinical Epidemiology, Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, USA;5. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;1. Graduate Program in Human Nutrition, University of Brasilia, Campus Universitário Darcy Ribeiro, Faculdade de Ciências da Saúde, Departamento de Nutrição, Brasília, DF, 70910-900, Brazil;2. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, 2-004 Li Ka Shing Center for Health Research Innovation, 113 St and 87 Ave NW, Edmonton, AB, T6G 2E1, Canada;3. Department of Applied Nutrition, Institute of Nutrition, Rio de Janeiro State University, Rua São Francisco Xavier, 524, Pavilhão João Lyra Filho, 12º andar, Bloco D, sala 12.023, Rio de Janeiro, RJ, 20559-900, Brazil;4. Graduate Program in Physical Education, University of Brasilia, Campus Universitário Darcy Ribeiro, Faculdade de Educação Física, Brasília, DF, 70910-9000, Brazil;1. Nutrition Department, CHU Rouen, Rouen, France;2. Université de Rouen Normandie, INSERM UMR 1073, Nutrition, Inflammation and Microbiota-gut-brain Axis, IRIB, Rouen, France;3. Clinical Investigation Centre CIC 1404, INSERM and CHU Rouen, Rouen, France;4. Université de Rouen Normandie, CNRS UMR 6085, Laboratory of Mathematics Raphael Salem, Rouen, France;1. Department of Urology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;2. Innovative and Clinical Research Promotion Center, Gifu University Hospital, 1-1, Yanagido, Gifu, 501-1194, Japan;3. Department of Urology, Osaka City General Hospital, 2-13-22, Miyakojimahondori, Miyakojima-ku, Osaka, 534-0021, Japan;4. Department of Nursing, Osaka Metropolitan University Hospital, 1-5-7, Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;5. Department of Nutrition, Osaka Metropolitan University Hospital, 1-5-7, Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;6. Department of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;7. Department of Nephrology and Diabetology, Meijibashi Hospital, 1-358-3, Miyakenishi, Matsubara-shi, Osaka, 580-0045, Japan
Abstract:
Keywords:Gastrointestinal symptoms  Gluten re-introduction  Gluten-free diet  Non-coeliac gluten sensitivity  Prolyl endoprotease
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