益肾解毒方延缓慢性肾功能衰竭的临床观察

目的：观察中药益肾解毒方对延缓慢性肾功能衰竭（CRF）进展的作用。方法：45例CRF患者分为两组，对照组（A组）22例单纯予低蛋白饮食及控制高血压治疗；治疗组（B组）23例在A组治疗基本上加用益肾解毒方治疗。以计算两组SCr值升高1倍时所经历的时间（月）之方法评估CRF的进展速度。结果：A组SCr由（288．4±96．7）μmol/L升高至（586．3±251．3）μmol/L历时（16．7±5．1）个月；B组SCr由（291．2±101．2）μmol/L 高至（589．6±257．5）μmol/L历时（28．2±8．7）个月，两组比较差异有显著性（P＜0．05）。结论：在低蛋白饮食和控制高血压的基础上加用中药益肾解毒方，可使CRF进展速度明显延缓。

Clinical Observation on Effect of Yishen Jiedu Recipe in Retarding the Course of Chronic Renal Failure

OBJECTIVE: To observe the effect of Yishen Jiedu Recipe (YSJDR) in retarding the course of chronic renal failure (CRF). METHODS: Forty-five patients were divided into two groups, the 22 patients in Group A were treated with low-protein diet and blood pressure controlling therapy only, while the 23 patients in Group B were treated with additional YSJDR. The time (month) for doubling serum creatinine (SCr) level was taken to evaluate the speed of CRF progression. RESULTS: In Group A, the time for SCr increased from 288.4 +/- 96.7 mumol/L to 586.3 +/- 251.3 mumol/L was 16.7 +/- 5.1 months, while in Group B the time for SCr increased from 291.2 +/- 101.2 mumol/L to 589.6 +/- 257.5 mumol/L was 28.2 +/- 8.7 months. Comparison between the two groups showed significant difference (P < 0.05). CONCLUSION: On the basis of low-protein diet and blood pressure controlling therapy, the additional treatment of YSJDR could markedly retard the progression speed of CRF.