PTTG‐1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy |
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| Authors: | Alexandros Iliadis Maria‐Aikaterini Virvili Nicolaos A. Flaris Stavroula Pervana Elissabet Pazarli Grigoris Tripsianis Maria E. Grigoriou Ioannis Efstratiou Dimitrios N. Kanakis |
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| Affiliation: | 1. Department of Pathology, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Laboratory of Developmental Biology & Molecular Neurobiology, Health Sciences School, Democritus University of Thrace, Alexandroupolis, Greece;3. Department of Pathology, “Hippokration” General Hospital, Thessaloniki, Greece;4. Department of Pathology, “Papageorgiou” General Hospital, Thessaloniki, Greece;5. Department of Medical Statistics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece;6. Medical School, University of Nicosia, Nicosia, Cyprus |
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| Abstract: | This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade‐I, 23 Grade‐II and 7 Grade‐III meningiomas. Mitotic index (MI), Ki‐67/MiB‐1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades. In comparison, PTTG expression was on a par with the other two indices, and performed very well regarding identification of advanced grade tumors. PTTG may be considered an important diagnostic tool and serve in the future as a novel prognosticator of the biological behavior of all grade meningiomas as well as a useful high‐risk patient selection tool. |
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| Keywords: | Pituitary tumor transforming gene meningioma Ki‐67 mitotic index WHO grade |
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