| 巯基壳聚糖性能的体外评价 |
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| 引用本文： | 吕占国,王立强. 巯基壳聚糖性能的体外评价[J]. 中国医药科学, 2011, 0(18): 36-37 |
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| 作者姓名： | 吕占国 王立强 |
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| 作者单位： | 解放军第二○二医院;华侨大学分子药物学研究所 |
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| 基金项目： | 福建省自然科学基金资助项目(2010J01208) |
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| 摘 要： | 目的研究和评价巯基壳聚糖各项性能。方法用重量法考察本产物的溶胀性能,并通过溶菌酶实验考察降解性能。结果本巯基壳聚糖的溶胀行为和未经修饰的聚合物在同一范围内,而且巯基壳聚糖可被溶菌酶生物降解。结论巯基壳聚糖是新型给药系统中很有前景的功能性敷料。
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| 关 键 词： | 巯基壳聚糖 二巯键 溶胀性 体外评价 |
Thiol chitosan in vitro evaluation of the performance |
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| LV Zhanguo,WANG Liqiang. Thiol chitosan in vitro evaluation of the performance[J]. China Medicine and Pharmacy, 2011, 0(18): 36-37 |
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| Authors: | LV Zhanguo WANG Liqiang |
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| Affiliation: | 1.202 Hospital of PLA,Shenyang 110016,China;2.Molecular PharmacologyInstitute of Huaqiao University,Quanzhou 362021,China |
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| Abstract: | Objective To study and evaluate the performance of sulfhydryl chitosan.Methods The study of the product weight method swelling properties and experimental study by lysozyme degradation.Results The swelling behavior of chitosan sulfhydryl and without modification of the polymer in the same range,and lysozyme sulfhydryl chitosan can be biodegradable.Conclusion Chitosan were a sulfhydryl promising new drug delivery system in the functional dressing. |
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| Keywords: | Thiol chitosan Disufide bond Sweuing property In vitro evaluation of the performance |
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