| 高效液相色谱法测定尼可刹米注射液的含量 |
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| 引用本文： | 姜锋卫. 高效液相色谱法测定尼可刹米注射液的含量[J]. 中国医药科学, 2011, 0(21): 87-88 |
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| 作者姓名： | 姜锋卫 |
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| 作者单位： | 河南省焦作市药品检验所 |
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| 摘 要： | 目的建立用高效液相色谱法测定尼可刹米注射液含量的方法。方法选用Eclipse DCB-C18色谱柱(150 mm×4.6 mm,5μm);以乙腈-水(20∶80)为流动相;流速1.0 mL/min,检测波长263 nm。结果尼可刹米在0.549～10.980 mg/mL范围内呈良好的线性关系(r=0.9993),平均加样回收率为100.6%(RSD=1.2%,n=6)。结论本方法准确、重复性好,可用作尼可刹米注射液的质量控制。
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| 关 键 词： | 尼可刹米注射液 高效液相色谱 含量测定 |
Determination the content of Nikethamide injection by HPLC |
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| JIANG Fengwei. Determination the content of Nikethamide injection by HPLC[J]. China Medicine and Pharmacy, 2011, 0(21): 87-88 |
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| Authors: | JIANG Fengwei |
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| Affiliation: | JIANG Fengwei Jiaozuo Institute for Food and Drug Control in Henan Province,Jiaozuo 454000,China |
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| Abstract: | Objective To establish a method for determination the content of Nikethamide injection by HPLC.Methods The Eclipse DCB-C18 column(150 mm×4.6 mm,5μm) was used.The mobile phase was acetonitrile-water(20 ∶ 80).The flow rate was 1.0 mL/min and the detection wavelength was 263 nm.Results The linear range of Nikethamide was 0.549~10.980 mg/mL(r=0.9993).The average recovery was 100.6%(RSD=1.2%,n=6).Conclusion This method is sensitive and reproducibility,it can be used for quality control of Nikethamide Injection. |
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| Keywords: | Nikethamide injection HPLC Content determination |
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