Lack of association between seroprevalence of Helicobacter pylori infection and primary biliary cirrhosis |
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Authors: | Durazzo Marilena Rosina Floriano Premoli Alberto Morello Enrico Fagoonee Sharmila Innarella Rosaria Solerio Enrico Pellicano Rinaldo Rizzetto Mario |
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Institution: | 1. Department of Internal Medicine, University of Turin, Turin, Italy 2. Department of Gastroenterology, Gradenigo Hospital, Turin, Italy 3. Department of Biology, Biochemistry and Genetics, University of Turin, Turin, Italy 4. Department of Gastroenterology,Molinette Hospital, Turin, Italy |
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Abstract: | AIM: To determine the association between seroprevalence of Helicobacter pylori (H pylori) infection and primary biliary cirrhosis (PBC). METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2+/-11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47+/-5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-H pylori (IgG) antibodies in serum. RESULTS: Antibodies to H pylori were present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P = 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of H pylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs 46.2%) P = 0.46, OR = 1.19, 95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pylori infection was similar between PBC-patients and controls (54.2% vs 57.8%, P = 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of H pylori infection and primary biliary cirrhosis. |
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