| 补阳还五汤对早期糖尿病肾病患者血管内皮生长因子及其受体Flt-1的影响 |
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| 引用本文： | 叶仁群,谢嘉嘉,林国彬,曾纪斌,宋晓容. 补阳还五汤对早期糖尿病肾病患者血管内皮生长因子及其受体Flt-1的影响[J]. 中国中西医结合肾病杂志, 2009, 10(2): 137-139 |
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| 作者姓名： | 叶仁群 谢嘉嘉 林国彬 曾纪斌 宋晓容 |
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| 作者单位： | 广东省深圳市宝安区中医院内科,深圳,518133 |
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| 基金项目： | 深圳市科技计划项目，深圳市宝安区科学技术局基金 |
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| 摘 要： | 目的：探讨补阳还五汤对早期糖尿病肾病患者血管内皮生长因子（VEGF）及其受体（Flt-1）的影响。方法：将60例早期糖尿病肾病患者随机分为治疗组和对照组，两组均用西药常规治疗，治疗组加服补阳还五汤。采用酶联免疫法检测各组血清VEGF及其受体Flt-1水平。结果：治疗组血清VEGF及其受体Flt-1水平较治疗前明显下降（P＜0．05），24h尿蛋白量较治疗前明显下降（P＜0．05），且治疗组优于对照组（P＜0．05）。VEGF、Flt—1与尿蛋白呈正相关。结论：VEGF及其受体Flt-1在早期糖尿病肾病发病机制中起重要作用，补阳还五汤可降低早期糖尿病肾病患者血清VEGF及其受体Flt—1蛋白表达，是其保护肾功能的可能作用机制之一。
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| 关 键 词： | 补阳还五汤 早期糖尿病肾病 血管内皮生长因子 受体 |
Effect of Buyang Huanwu Decoction on Vascular Endothelial Growth Factor And its Receptor Fit-1 in Early Diabetic Nephropathy Patients |
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| YE Renqun,XIE Jiajia,LIN Guobin,et al Traditional Chinese Medical Hospital in Bao''an Districtof Shenzhen City,Shenzhen. Effect of Buyang Huanwu Decoction on Vascular Endothelial Growth Factor And its Receptor Fit-1 in Early Diabetic Nephropathy Patients[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2009, 10(2): 137-139 |
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| Authors: | YE Renqun XIE Jiajia LIN Guobin et al Traditional Chinese Medical Hospital in Bao''an Districtof Shenzhen City Shenzhen |
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| Abstract: | Objective:To explore the effect of buyang huanwu decoction(BYHWD) on vascular endothelial growth factor(VEGF) and its receptor Flt-1 in early diabetic nephropathy patients.Methods:Sixty cases of early diabetic nephropathy were randomly divided into two groups.The treatment group was treated with BYHWD,the control was treated without BYHWD.Two groups were received routine western treatment.The treatment group was treated with BYHWD.The levels of VEGF and Flt-1 in plasma of every group were measured by immuno... |
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| Keywords: | Buyang huanwu decoction Early diabetic nephropathy VEGF Flt-1 |
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