γ-d-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice |
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| Authors: | M.J. Croucher B.S. Meldrum A.W. Jones J.C. Watkins |
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| Affiliation: | 1. The University Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF U.K.;2. The Department of Pharmacology, The Medical School, University Walk, Bristol, BS8 1TD U.K. |
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| Abstract: | The effect of gamma-D-glutamylaminomethylsulphonic acid (GAMS) on sound-induced seizures has been assessed in DBA/2 mice. All phases of the seizure response are suppressed following intracerebroventricular injection (ED50 values: 0.077 mumol for tonic seizure, 0.132 mumol for wild running) or intraperitoneal injection (ED50: 1.21 mmol/kg for tonic seizure, 4.95 mmol/kg for wild running). The results are discussed in relation to the involvement of 'kainate' and 'quisqualate' receptors in the generation and propagation of seizures. |
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| Keywords: | epilepsy excitatory amino acid antagonists kainic acid anticonvulsants |
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