| 胃肠激素与肠易激综合征的相关性 |
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| 引用本文： | 林琳,赵志泉,殷咏梅,阎验,林征. 胃肠激素与肠易激综合征的相关性[J]. 江苏医药, 2001, 27(3): 166-168 |
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| 作者姓名： | 林琳 赵志泉 殷咏梅 阎验 林征 |
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| 作者单位： | 南京医科大学第一附属医院消化科 |
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| 基金项目： | 本课题受江苏省教育厅自然科学基金资助（项目编号：98KJD320007） |
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| 摘 要： | 目的：研究血管活性肠肽（VIP），P物质（SP）和酷神经肽（NPY）在肠易激综合征（IBS）患者血浆和乙状结肠粘膜中的变化及临床意义。方法：用放射免疫法分别检测IBS患者（40例）和正常对照组（15例）血浆和乙状结肠粘膜中以上三种激素的含量。结果：IBS患者血浆和乙 状结肠粘膜中NPY含量明显低于对照组（P＜0．05），而IP和SP在血浆中含量与正常对照组无显著差异（P＞0．015），在乙状结肠粘膜中含量明显高于对照组（P＜0．01），结论：P乙状结肠粘膜中三种胃肠激素的变化在IBS的腹痛，腹泻发病中有一定作用。
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| 关 键 词： | 肠易激综合征 血管活性肠肽 酷神经肽 P物质 胃肠激素 |
| 修稿时间： | 2000-08-26 |
The relationship betweengastrointestinal hormones and irritable bowel syndrome |
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| Abstract. The relationship betweengastrointestinal hormones and irritable bowel syndrome[J]. Jiangsu Medical Journal, 2001, 27(3): 166-168 |
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| Authors: | Abstract |
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| Abstract: | Objective To investigate the change and clinical significance of Vasoactive intestinal polypeptide(VIP),Substance P(SP) and Neuropeptide tyrosine (NPY) in irritable bowel syndrome (IBS) Methods The VIP,SP and NPY in plasma and sigmoid mucosa were measured by the radioimmunoassay(RIA) in normal group( n =15) and the IBS group( n =40) Results The plasma and sigmoid mucosa NPY was significantly lower than that in the normal group( P <0 05),while the plasma VIP and SP had no significant differences( P >0 05),but the VIP and the SP of the sigmoid mucosa were significantly higher than that in the normal group( P <0 01) Conclusion The change of these three gastrointestinal hormones may play some role in the pathogenesis of IBS |
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| Keywords: | Irritable bowel syndrome Vasoactive intestinal polypeptide Neuropeptide tyrosine Substance P |
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