Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference |
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| Authors: | Rozeske Robert R Greenwood Benjamin N Fleshner Monika Watkins Linda R Maier Steven F |
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| Affiliation: | University of Colorado-Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA. rozeske@colorado.edu |
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| Abstract: | In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP. |
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