Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine |
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| Authors: | Seung U. Kim Masanori Tomonaga Bernardino Ghetti |
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| Affiliation: | (1) Division of Neuropathology (Department of Pathology), University of Pennsylvania School of Medicine, 19104 Philadelphia, PA, USA;(2) Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;(3) Division of Neuropathology (Department of Pathology), Indiana University School of Medicine, 46202 Indianapolis, IN, USA |
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| Abstract: | Summary The effects of maytansine, an antimitotic compound isolated from an African plant, were studied by light and electron microscopy in dissociated cell cultures of adult mouse dorsal root ganglia.Maytansine at 10–100 ng/ml concentration caused reversible, concentration-dependent, inhibition of microtubule assembly and induction of a large amount of 10 nm filaments in the cytoplasm of cultured neurons and Schwann cells.This work was supported by USPHS grants NS-10648, NS-15205 and RCDA award NS-00151 |
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| Keywords: | Neurofibrillary degeneration Maytansine Adult mouse Dorsal root ganglion Tissue culture Aging |
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