支气管肺炎患儿治疗前后血清SIL-2R和T淋巴细胞亚群的水平探讨

目的：探讨了血清可溶性白细胞介素-2受体（SIL-2R）和T淋巴细胞亚群水平在支气管肺炎患儿治疗前后的变化及意义.方法：应用双抗体夹心ELISA和单克隆抗体法对33例支气管肺炎病儿进行了治疗前后血清SIL-2R和T淋巴细胞亚群测定,并与30例正常儿作比较.结果：支气管肺炎病儿在治疗前血清SIL-2R水平显著地高于正常儿组（P＜0.01）.治疗后2周血清SIL-2R水平与正常儿比较无显著性差异（P＞0.05）,SIL-2R与T淋巴细胞亚群中CD8细胞比值密切相关.结论：检测支气管肺炎病儿血清中SIL-2R和T淋巴细胞亚群水平可作为病情预后判断的重要指标.

Study on the Changes of Serum Soluble IL-2 Receptor (SIL-2R) Levels and Distribution Pattern of Peripheral Blood T-cell Subsets After Treatment in Pediatric Patients with Bronchopneumonia

Objective To investigate the significance of changes of serum SIL-2R levels and T-cell subsets distribution type after treatment in pediatric patients with bornchopneumonia. Methods Serum SIL-2R levels (with ELISA) and peripheral blood T-cell subset distribution pattern (with monoconal antibody technique) were determined in 33 pediatric patients with broncho-preumonia and 30 controls. Results Before treatment, the serum SIL-2R levels in the patients were significantly higher than those in normal controls (P<0.01). After treatment for two weeks the SIL-2R levels in the two groups were about the same (P>0.05). Serum SIL-2R levels were positively corrleated with CD4/CD8 ratio. Conclusion Detect of serum SIL-2R levels and CD4/CD8 ratio is clinically useful in the management of pediatric patients with bronchopneumonia.