子宫内膜异位症合并不育患者体外受精-胚胎移植治疗结局分析

目的:观察体外受精-胚胎移植(IVF-ET)治疗周期子宫内膜异位症对IVF-ET治疗结果的影响。方法:22例23个周期子宫内膜异位症合并不育症患者(A组)以及同期随机抽取36例36个周期输卵管性不育患者(B组)进行对比,从使用Gn量、使用Gn天数、获卵数、卵裂数、受精数以及临床妊娠率等方面进行比较分析。结果:Gn用量、Gn用药天数有统计学意义(P<0.05),获卵数、受精数、卵裂数、种植率、临床妊娠率比较差异无显著性(P>0.05)。结论:子宫内膜异位症患者卵巢储备能力下降,促性腺激素用量增加,但卵母细胞受精能力,胚胎种植率和临床妊娠率与输卵管性因素不育结果相似。

The Retrospective Analysis on the Outcome of IVF-ET for Patients with Infertility by Endometriosis

Objective:Tto investigate and analyze the effect of endometriosis on in vitro fertilization and embryo transfer according to the comparison between the infertility patients with endometriosis or tubal-factor.Methods:Twenty-two patients with endometriosis(group A) underwent 23 cycles of IVF-ET.The matched control group with tubal-factor infertility(group B) consisted of 36 cycles in 36 patients.These groups were analyzed regarding stimulation,fertilization,cleavage,implantation,and pregnancy outcome.Results:The requirement of gonadotropin and the days of controlled ovarian hyperstimulation(COH) higher(P<0.05),but the cleavage,fertilization,implantation,and pregnancy rate did not differ between the two groups.Conclusion:Our results show that women with endometriosis presented a poor ovarian response to controlled ovarian hyperstimulation,but the ability for the oocyte to be fertilized,the implantation and pregnancy rate were similar to the tubal-factor infertility.