| C-FOS和BCL-2在兔颈髓组织中的抗缺血作用 |
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| 引用本文： | 邓天琼,张怡五,杨星华,王晓勇,任先军. C-FOS和BCL-2在兔颈髓组织中的抗缺血作用[J]. 西南国防医药, 2006, 16(6): 586-588 |
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| 作者姓名： | 邓天琼 张怡五 杨星华 王晓勇 任先军 |
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| 作者单位： | 1. 解放军第324医院骨科,重庆,400020
2. 第三军医大学新桥医院骨科,重庆,400038 |
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| 基金项目： | 全军“十五”课题基金资助项目(01MB114) |
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| 摘 要： | 目的:研究C-FOS和BCL-2在颈髓缺血中的作用。方法:结扎兔双侧椎动脉颈段,用LDF测定颈髓血流,观察兔颈髓组织细胞免疫组化的变化。结果:术后4 h组C-FOS和BCL-2在颈髓组织中表达明显增强,术后56 d组无明显改变。结论:C-FOS和BCL-2在颈髓缺血中具有一定程度的抗缺血作用。
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| 关 键 词： | C-FOS、BCL-2 颈髓 抗缺血 |
| 文章编号： | 1004-0188（2006）06-0586-03 |
| 收稿时间： | 2006-08-08 |
| 修稿时间： | 2006-08-08 |
Role of C- FOS and BCL- 2 in anti - ischemia in cervical spinal cord in rabbits |
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| DENG Tian-qiong,ZHANG Yi-wu,YANG Xin-hua,WANG Xiao-yong,REN Xian-jun. Role of C- FOS and BCL- 2 in anti - ischemia in cervical spinal cord in rabbits[J]. Medical Journal of National Defending forces in Southwest China, 2006, 16(6): 586-588 |
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| Authors: | DENG Tian-qiong ZHANG Yi-wu YANG Xin-hua WANG Xiao-yong REN Xian-jun |
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| Affiliation: | 1. Department of Orthopedics, Hospital 324 of PI.A, Chongqing, 400020;2..Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, 400038. |
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| Abstract: | Objective:To study the role of C-FOS and BCL-2 in ischemia in cervical spinal cord after complete ligation vertebral artery in rabbits.Methods:Bilateral vertebral arteries of rabbits were ligated at C6 and C7 segment,then the changes of cell morphology and immunohistochemistry in the cervical spinal cord were observed and the blood flow was measured by laser Doppler Flowmetry(LDF)after 4 hours,8 hours and 56 days.Result:Except the 56 day group,the blood flow in cervical spinal cord changed markedly.Acute ischemic changes were observed after 8 hours and 24 hours,but no changes were observed after 4 hours and 56 days.The expression of C-FOS and BCL-2 in 4 hour and 8 hour groups were more significant than that in the control group and 56 day group.Conclusion:C-FOS and BCL-2 may play a role of anti-ischemia in cervical spinal cord. |
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| Keywords: | C-FOS BCL-2 ischemia cervical spinal cord |
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