静脉注射多柔比星对血管内膜损伤的病理学研究 |
| |
引用本文: | 陈萍,向梅,何红燕,宁四清,胡华琼,陶红,莫慧琴. 静脉注射多柔比星对血管内膜损伤的病理学研究[J]. 山西护理杂志, 2009, 0(11): 2836-2837 |
| |
作者姓名: | 陈萍 向梅 何红燕 宁四清 胡华琼 陶红 莫慧琴 |
| |
作者单位: | 湖北省襄樊市中心医院,441021 |
| |
基金项目: | 为襄樊市中心医院科研课题立项与基金资助项目,编号:2006.C22. |
| |
摘 要: | [目的]观察两种浓度的多柔比星静脉推注对免血管内膜的损伤程度。[方法]选择24只大白兔,分为对照组和实验组,对照组多柔比星浓度为1.0mg/mL;实验组多柔比星浓度为0.5mg/mL。分别在兔左右耳缘静脉推注,且在推注后48h、2周分别取左右耳缘静脉血管组织标本进行病理学分析。[结果]推注48h后两组兔血管内膜损伤程度比较,差异有统计学意义(P〈0.01);推注2周后两组免血管内膜损伤程度亦存在差异(P〈0.01)。E结论]静脉推注低浓度(0.5mg/m1.)多柔比星,能明显减轻对血管内膜的损伤,从而有效保护血管,降低静脉炎发生率。
|
关 键 词: | 多柔比星 静脉注射 药物浓度 血管内膜 |
Pathological study on intravenous injection of doxorubicin caused vascular intimal injury |
| |
Affiliation: | Chen Ping, Xiang Mei, He Hongyan, et al (Central Hospital of Xiangfan City Hubei Province,Hubei 441021 China) |
| |
Abstract: | Objective:To observe the degrees of intimal injury of rabbits after accepting intravenous injection of two different concentrations of doxorubi- tin. Methods:A total of 24 rabbits were divided into control and test group randomly. Rabbits in control group were injected doxorubicin with concentra- tions of 1.0 mg/mL. Rabbits in test group were injected 0.5 mg/mL doxoru- bicin. Both right and left ear vein were injected in the same time in each group. And the ear vein tissues were collected at 48 hours and 2 weeks after intravenous injection doxorubiein respectively. Results: Compared the vascu- lar intimal injury degrees of the two groups at 48 hours after intravenous in- jection doxorubicin,there was statistical significant difference between them (P~0.01). There was statistical significant difference in terms of vascular intimal injury degrees 2 weeks later between the two groups (P~0.01). Conclusion:Intravenous injection lower concentration (0. 5 mg/mL) of doxo- rubicin can reduce the vascular intimal injury of rabbits,so as to protect the blood vessels, and to decrease the incidence of phlebitis of rabbits. |
| |
Keywords: | doxorubicin intravenous injection drug concentration vascular intimal injury |
本文献已被 维普 等数据库收录! |
|