大肠癌恶病质中医证型研究

目的初步探讨大肠癌恶病质的中医辨证分型,为中医辨证论治大肠癌恶病质提供客观科学的依据。方法通过制定回顾性临床观察表,收集符合纳入标准的病历共106例;将患者的各项临床指标作为变量输入计算机,建立SAS数据库。对所有症状、舌、脉进行频数统计分析,删除各证候中指标出现频率很小(小于10%)的变量;对所有患者的症状进行聚类分析。结果大肠癌恶病质患者症状分布特点以纳呆食少、腹痛、口淡乏味、神疲乏力、恶心为主要症状,分别占98.11%、83.02%、83.02%、81.13%和77.36%。通过聚类分析,结合专业知识,总结出大肠癌恶病质常见的六个证型:脾虚气滞证、气血两虚证、气阴两虚证、脾虚湿阻证、肠腑不通证和脾胃虚寒证。结论通过数理统计的方法,总结出大肠癌恶病质中医辨证分为六型,为大肠癌恶病质的临床治疗提供了客观依据。

Pattern/Syndrome Study of Cachexia of Large Intestine Cancer in Chinese Medicine

Objective To explore primarily the pattern/syndrome differentiation of cachexia of large intestine cancer in Chinese medicine so as to provide the objective evidences for the treatment based on the pattern/syndrome differentiation in Chinese medicine. Methods Collect totally 106 cases that met the inclusive standards by implementing the retrospective clinical observation form, take every clinical index as the variant and input into the computer to set up SAS database. Conduct the frequency statistical analysis on all the symptoms, tongue and pulse, delete the variants with lower frequency in every syndrome index （less than 10% ）and have a cluster analysis for all the symptoms. Results Anorexia, lumbago, tastelessness, lassitude and nausea were predominated in the symptom distribution for the patients with cachexia of large intestine cancer, accounting for 98.11% ,83.02% ,83.02%, 81.13% and 77.36% successively. By the cluster analysis and the summary of professional knowledge, six common patterns/syndromes of cachexia of large intestine cancer were summarized, named spleen deficiency and qi stagnation, qi and blood deficiency, qi and yin deficiency, spleen deficiency and blockage of damp, obstruction of intestine, and deficiency and cold of the spleen and stomach. Conclusion By mathematical statistics, six patterns/syndromes of cachexia of large intestine cancer have been summarized,which provides the objective evidences for the clinical treatment of cachexia of large intestine cancer.