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Excitation-contraction coupling and relaxation alteration in right ventricular remodelling caused by pulmonary arterial hypertension

Institution:	1. Faculté de médecine, Université Paris-Saclay, 94270 Le Kremlin Bicêtre, France;2. Service de pneumologie, Centre de référence de l’hypertension pulmonaire, Hôpital Bicêtre, AP–HP, 94270 Le Kremlin Bicêtre, France;3. Inserm UMR-S 999, Hôpital Marie Lannelongue, 92350 Le Plessis Robinson, France;4. Inserm UMR-S 1180, Signalisation et Physiopathologie Cardiovasculaire, Université Paris-Saclay, 92296 Châtenay-Malabry, France

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Keywords:	Excitation-contraction coupling Orai1 TRPC KCNK3 PAH Right ventricle Couplage excitation-contraction Orai1 TRPC KCNK3 HTAP Ventricule droit AP"} {"#name":"keyword" "$":{"id":"kw0075"} "$$":[{"#name":"text" "_":"Action potential Calcium CH"} {"#name":"keyword" "$":{"id":"kw0105"} "$$":[{"#name":"text" "_":"Chronic hypoxia CTEPH"} {"#name":"keyword" "$":{"id":"kw0115"} "$$":[{"#name":"text" "_":"Chronic thromboembolic pulmonary hypertension ECC"} {"#name":"keyword" "$":{"id":"kw0125"} "$$":[{"#name":"text" "_":"Excitation-contraction coupling KCNK3/TASK-1 current Inositol trisphosphate receptor subtype 2 Potassium KCNK3/TASK-1"} {"#name":"keyword" "$":{"id":"kw0215"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"TWIK-related acid-sensitive K"} {"#name":"sup" "$":{"loc":"post"} "_":"+"} {"#name":"__text__" "_":" channel Kir"} {"#name":"keyword" "$":{"id":"kw0225"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Inward-rectifier K"} {"#name":"sup" "$":{"loc":"post"} "_":"+"} {"#name":"__text__" "_":" channel Kv"} {"#name":"keyword" "$":{"id":"kw0235"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Voltage-gated K"} {"#name":"sup" "$":{"loc":"post"} "_":"+"} {"#name":"__text__" "_":" channel LV"} {"#name":"keyword" "$":{"id":"kw0245"} "$$":[{"#name":"text" "_":"Left ventricular MCT"} {"#name":"keyword" "$":{"id":"kw0255"} "$$":[{"#name":"text" "_":"Monocrotaline mPAP"} {"#name":"keyword" "$":{"id":"kw0265"} "$$":[{"#name":"text" "_":"Mean pulmonary arterial pressure mRNA"} {"#name":"keyword" "$":{"id":"kw0275"} "$$":[{"#name":"text" "_":"Messenger ribonucleic acid NCX"} {"#name":"keyword" "$":{"id":"kw0285"} "$$":[{"#name":"text" "_":"Sodium-calcium exchanger PAB"} {"#name":"keyword" "$":{"id":"kw0295"} "$$":[{"#name":"text" "_":"Pulmonary arterial banding PAH"} {"#name":"keyword" "$":{"id":"kw0305"} "$$":[{"#name":"text" "_":"Pulmonary arterial hypertension PH"} {"#name":"keyword" "$":{"id":"kw0315"} "$$":[{"#name":"text" "_":"Pulmonary hypertension RV"} {"#name":"keyword" "$":{"id":"kw0325"} "$$":[{"#name":"text" "_":"Right ventricle/ventricular RVF"} {"#name":"keyword" "$":{"id":"kw0335"} "$$":[{"#name":"text" "_":"Right ventricular failure RVH"} {"#name":"keyword" "$":{"id":"kw0345"} "$$":[{"#name":"text" "_":"Right ventricular hypertrophy RyR2"} {"#name":"keyword" "$":{"id":"kw0355"} "$$":[{"#name":"text" "_":"Ryanodine receptor 2 SERCA"} {"#name":"keyword" "$":{"id":"kw0365"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Sarco/endoplasmic reticulum Ca"} {"#name":"sup" "$":{"loc":"post"} "_":"2+"} {"#name":"__text__" "_":"-adenosine triphosphatase SOCE"} {"#name":"keyword" "$":{"id":"kw0375"} "$$":[{"#name":"text" "$$":[{"#name":"__text__" "_":"Store-operated Ca"} {"#name":"sup" "$":{"loc":"post"} "_":"2+"} {"#name":"__text__" "_":" entry SR"} {"#name":"keyword" "$":{"id":"kw0385"} "$$":[{"#name":"text" "_":"Sarcoplasmic reticulum STIM"} {"#name":"keyword" "$":{"id":"kw0395"} "$$":[{"#name":"text" "_":"Stromal interaction molecule STIM1L"} {"#name":"keyword" "$":{"id":"kw0405"} "$$":[{"#name":"text" "_":"Long stromal interaction molecule SU/Hx"} {"#name":"keyword" "$":{"id":"kw0415"} "$$":[{"#name":"text" "_":"Sugen 5416/hypoxia TAPSE"} {"#name":"keyword" "$":{"id":"kw0425"} "$$":[{"#name":"text" "_":"Tricuspid annular plane systolic excursion TRPC"} {"#name":"keyword" "$":{"id":"kw0435"} "$$":[{"#name":"text" "_":"Transient receptor potential canonical
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