Phytochemical and Pharmacological Investigation of Ethanol Extract of Cissampelos pareira |
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| Authors: | H M Reza M Shohel Sadia B Aziz Farzana I Pinaz M F Uddin M Al-Amin I N Khan Preeti Jain |
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| Institution: | Department of Pharmacy, North South University, Dhaka, Bangladesh;1.Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh |
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| Abstract: | In this study, the ethanol extract of Cissampelos pareira has been evaluated. The extract was tested for analgesic properties using both hot plate and acetic acid-induced writhing methods. Antiinflammatory effect was investigated using two different doses of 250 and 500 mg/kg body weight on Evans rats by carrageenan-induced paw edema test. The antipyretic activity was evaluated using Brewer''s yeast-induced pyrexia in Wistar rats. The phytochemical screening of the extract of Cissampelos pareira exhibited the presence of several phytochemical compounds including saponins, gums and carbohydrates, reducing sugars, alkaloids and terpenoids. Ethanol extract of Cissampelos pareira exhibited significant analgesic, antiinflammatory and antipyretic activity in a dose-dependent manner. The results obtained from these studies confirm its therapeutic value against diseases caused by various pain and fever. |
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| Keywords: | Cissampelos pareira analgesic antioxidant antiinflammatory antipyretic carrageenan-induced paw edema yeast |
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