Factors associated with Clostridium difficile diarrhea
in a hospital in Beijing,China |
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Authors: | Z Lv GL Peng JR Su |
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Institution: | Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China |
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Abstract: | Clostridium difficile is the most common cause of hospital-acquired
diarrhea in patients treated with antibiotics, chemotherapeutic agents, and other
drugs that alter the normal equilibrium of the intestinal flora. A better
understanding of the risk factors for C. difficile-associated
disease (CDAD) could be used to reduce the incidence of CDAD and the costs associated
with its treatment. The aim of this study was to identify the risk factors for CDAD
in a cohort of Chinese patients in a Beijing hospital. Medical charts of a total of
130 inpatients (62 males and 68 females) with hospital-acquired diarrhea (45 with
CDAD; 85 without CDAD) were retrospectively reviewed. C. difficile
toxins A and B were detected in fecal samples using enzyme-linked fluorescence
assays. The drugs used by patients with and without CDAD before the onset of diarrhea
were compared. Factors that differed significantly between the two groups by
univariate analysis were analyzed by multivariate analysis using a logistic
regression model. Multivariate analysis showed that cephalosporin treatment was
associated with a significantly higher risk of CDAD in hospitalized patients, while
treatment with glycopeptides was significantly associated with a reduction in CDAD
(P<0.001 for cephalosporin; P=0.013 for glycopeptides). Our data confirmed
previous findings that empirical treatment with cephalosporins is positively
associated with CDAD compared to individuals using other CDAD-related drugs.
Additionally, we showed that treatment with glycopeptides was negatively associated
with CDAD, compared to individuals using other CDAD-related drugs. |
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Keywords: | Antibiotics Clostridium difficile Glycopeptides |
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